International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 13 - ASSESSING GENOMIC VARIATION IN COMMON STRAINS OF  INBRED MICE

Cervino ACL, Edwards S, Schadt E

rosetta/merck, seattle, United States

We characterized DNA variation in 60 different strains of mice, including 56 common strains ordered from the Jackson Laboratories. Using phylogenetic analysis we investigated how various common strains relate to each other. Insight into heterozygosity between strains and between markers is essential in the selection of both an optimal set of strains  and an optimal set of markers for the experimental crosses aimed at elucidating complex phenotypes. In addition to the survey of genomic variation we also investigated a number of clinically relevant phenotypes and gene expression profiles in a subset of strains.

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