International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 14 - EVOLUTIONARY BREAKPOINTS IN MOUSE, RAT AND HUMAN CHROMOSOMES

Elliott RW

Roswell Park Cancer Institute, Buffalo, United States

Positions of loci on sequence-based maps of several mouse chromosomes have been compared to the positions of orthologs in rat and human chromosomes.  There are about 10 to 15 evolutionary-based breaks for human chromosomes on each mouse chromosome, although mouse chr 15 has only 3 such breaks.  The number of breaks for rat chromosomes is usually much fewer, ranging from 0 to 11.  However, most of the break points between rat and mouse occur at the same position as mouse to human breakpoints.  This suggests that very few breaks have occurred between mouse and rat after the divergence of the rodent lineage, and that most pre-existed in earlier the mammalian genome.  Exceptions appear to be chromosome inversions, which are illustrated by the analysis of mouse Chr 17 and its rat and human orthologs.

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