International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


Functional Genome Analysis

POSTERS 53 - 85

53. IDENTIFICATION OF THE MOLECULAR MECHANISMS INVOLVED IN THE DEVELOPMENT OF HAIRLESS PHENOTYPE IN NEAR NAKED HAIRLESS (HRN) MICE
Liu YT 1, Das S 2, Olszewski RE 2, Lu XC 3, Voy BH 2
1 University of Tennessee, Knoxville, United States, 2 Oak Ridge National Lab, Oak Ridge, United States, 3 Lawrence Livermore National Laboratory, Livermore, United States

54. IDENTIFICATION OF MULTIPLE GENETIC LOCI LINKED TO LUNG FUNCTION IN MICE
Reinhard C 1, Meyer B 3, Fuchs H 2, Stöger T 1, Eder G 1, Rüschendorf F 3, Heyder J 1, Nürnberg P 3, Hrabé de Angelis M 2, Schulz H 1
1 Institute for Inhalation Biology, GSF-Research Center for Environment and Health, Neuherberg/Munich, Germany, 2 Institute of Experimental Genetics, GSF-Research Center for Environment and Health, Neuherberg/Munich, Germany, 3 Gene Mapping Center, Max-Delbrück-Centrum, Berlin, Germany

55. 'ANONYMUS' - A LABORATORY INFORMATION MANAGEMENT SYSTEM FOR THE CAPTURE AND DISSEMINATION OF ANIMAL HUSBANDRY AND EXPERIMENTAL DATA
Jones JD 1, Brundrett AC 1, Chandrasekar K 2, Jones PJR 1, Olver GH 2, Oxspring RJ 1, Seymour M 1, Selley RL 1, Johnson R 1
1 Mary Lyon Centre, Medical Research Council, Harwell, United Kingdom, 2 Prion Unit, Medical Research Council, London, United Kingdom

56. IMPAIRED THALAMIC SENSORY GATING AND AFFECTIVE DISORDER IN T-TYPE CA2+ CHANNEL MUTANTS
Shin H-S, Choi S, Lee J, Lee S, Kim C, Kim D
Korea Institute of Science & Technology, Seoul, Korea, South

57. A GENETIC ANALYSIS OF BEHAVIORAL DIVERSITY BETWEEN WILD-DERIVED MOUSE STRAIN, MSM/MS AND C57BL/6
Nishi A 1, Nishi A 3, Yonekawa H 2, Shiroishi T 1, Shiroishi T 4, Koide T 1, Koide T 3
1 The Graduate University of Advanced Studies, Hayama, Japan, 2 The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 3 Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Japan, 4 Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan

58. DESCRIPTIVE AND TEMPORAL ANALYSIS OF THE OPEN-FIELD BEHAVIOR IN WILD-DERIVED MOUSE STRAINS
Takahashi A 1, Takahashi A 4, Yonekawa H 2, Shiroishi T 1, Shiroishi T 3, Koide T 1, Koide T 4
1 The Graduate University of Advanced Studies, Mishima, Japan, 2 The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 3 Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan, 4 Mouse Genomics Resource Laboratory, National Institute of Genetics, Mishima, Japan

59. GENETIC AND BIOCHEMICAL CHARACTERIZATION OF AN ALLELIC SERIES OF SMAD4 MUTATIONS IDENTIFIED IN AN ENU-MUTAGENIZED MOUSE EMBRYONIC STEM CELL LIBRARY
Chen Y, Yee D, Magnuson T
University of North Carolina-Chapel Hill, Chapel Hill, United States

60. IDENTIFICATION OF POSITIONAL CANDIDATE GENES FOR GROWTH AND OBESITY
Aksu S, Neuschl C, Renne U, Koczan D, Thiesen HJ, Brockmann GA
Humboldt-University of Berlin, Berlin, Germany

61. ENU MUTAGENESIS IDENTIFIES A RECESSIVE MUTATION IN A DNAJ PROTEIN THAT RESULTS IN RETARDED GROWTH AND POLYDACTYLY
Webb T 1, McKie L 1, West K 1, Peters J 2, Cross SH 1, Jackson I 1
1 MRC Human Genetics Unit, Edinburgh, United Kingdom and 2 MRC Mammalian Genetics Unit, Harwell, United Kingdom

62. THE MOUSE JUVENILE SPERMATOGONIAL DEPLETION (JSD) PHENOTYPE IS DUE TO A MUTATION IN MUTP14B, A MEMBER OF THE SNORNP COMPLEX
Rohozinski J 1, Bishop CE  2
1 Baylor College of Medicine, Dept. Obstetrics & Gynecology, Houston, United States, 2 Baylor College of Medicine, Dept. Molecular & Human Genetics, Houston, United States

63. MUTATIONS IN THE MOUSE AXONEMAL DYNEIN HEAVY CHAIN, DNAHC2, RESULT IN MALE INFERTILITY
Meehan TP, Justice MJ
Baylor College of Medicine, Houston, United States

64. MOUSE DEAFNESS MUTANT LINES FROM THE RIKEN ENU MUTAGENESIS PROJECT
Minowa O, Inoue M, Sakuraba Y, Motegi H,  Toki H, Tada M, Kaneda H, Ishijima J, Masuya H, Kobayashi K, Suzuki T, Wakana S, Gondo Y, Shiroishi T, Noda T
RIKEN-GSC, Yokohama, Japan

65. MICROARRAY ANALYSIS OF GENE EXPRESSION AT THE DEL(13)SVEA36H REGION OF MOUSE CHROMOSOME 13 DURING POSTIMPLANTATION MOUSE DEVELOPMENT
Willoughby C 1, Davies J 1, Underhill P 1, Holmes C 1, Greenfield A 1, Denny P 1, Ragoussis J 2, Arkell R 1
1 Mammalian Genetics Unit, MRC Harwell, Oxfordshire, United Kingdom, 2 Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

66. MAPPING AND POSITIONAL CLONING OF ENU-INDUCED MOUSE DEVELOPMENTAL MUTANTS WITH A WHOLE GENOME SNP PANEL AND EXON-BASED SEQUENCING
Moran JL 1, Yun Y 1, Brown A 1, Bjork BC 1, Tran P 1, Li C 2, Salinger AP 3, Poirier C 3, Zhang B 1, Montgomery K 1, Bishop C 3, Justice M 3, Wiltshire T 4, Kwiatkowski DJ 1, Kucherlapati R 1, Beier DR 1
1 Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2 Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, United States, 3 Baylor College of Medicine, Houston, TX, United States, 4 Genomics Institute of the Novartis Research Foundation, San Diego, CA, United States

67. PHENOTYPE OR GENOTYPE? THE ORGANISM FROM DIFFERENT BIOLOGICAL PERSPECTIVES
Eppig JT, van den Borre P, Lu I, Anagnostopoulos A, Burkart DL, Cassell MA, Dene H, Bello SM, Washburn LL, Lutz CM, Goldsmith CW, Smith CL
The Jackson Laboratory, Bar Harbor, United States

68. SOPDB: A RESOURCE OF STANDARD OPERATING PROCEDURES FOR MOUSE PHENOTYPING
Green ECJ, Gkoutos GV, Weekes J, Mallon AM, Hancock JM
Mammalian Genetics Unit, Oxfordshire, United Kingdom

69. STUDY OF THE GENES INVOLVED IN THE HYPERTROPIC LANGERHANS ISLAND OF THE KK-AY MOUSE AND THEIR HISTOLOGICAL LOCALIZATION
Kusakabe M 1, Matsuba K 2, Inoue J 2, Aotsuka S 2, Hokao R 1, Hashimoto H 3
1 Institute for Animal Reproduction, Ibaraki, Japan, 2 ANB Tsukuba Institute, Aloka Co., Ltd., Ibaraki, Japan, 3 Jikei Univ. Sch of Med., Dept. Anat., Tokyo, Japan

70. IDENTIFICATION AND LOCALISATION OF MUTATIONS IN THE DEL(13)SVEA36H DELETION
McKeone R, Rowe C, Polley S, Wells S, Arkell R, Davies J, Bogani D, Dear N, Denny P
MRC Harwell, Didcot, United Kingdom

71. BEHAVIORAL CHARACTERIZATION AND LINKAGE ANALYSIS OF AN ENU-INDUCED MOUSE MUTANT LINE THAT SHOWS LEARNING DEFICIT, REDUCTION OF BODY SIZE, CONVULSIVE SEIZURE, AND TRANSIENT IMMOBILITY
Furuse T, Wada Y, Masuya H, Kaneda H, Kobayashi K, Kawai A, Kushida T, Nishii R, Gondo Y, Noda T, Wakana S, Shiroishi T
RIKEN GSC, Tsukuba, Japan

72. THE NOX3 AND NOXO1 GENES, ENCODING PRESUMPTIVE MEMBERS OF AN NADPH OXIDASE COMPLEX, ARE REQUIRED FOR NORMAL VESTIBULAR FUNCTION AND DEVELOPMENT
Bergstrom DE 1, Bergstrom RA 1, Munroe RJ 2, Schimenti JC 2, Gagnon LH 1, Johnson KR 1, Heinzmann U 3, Stumm G 4, Paffenholz R 4
1 The Jackson Laboratory, Bar Harbor, United States, 2 Cornell University, Ithaca, United States, 3 GSF-National Research Center for Environmental Health, Neuherberg, Germany, 4 Ingenium Pharmaceuticals, Martinsried, Germany

73. HOLOPROSENCEPHALY AT DEL(13)SVEA36H
Bogani D 1, Willoughby C 1, Mirza G 2, Davies J 1, Ragoussis I 2, Arkell R 1
1 Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, United Kingdom, 2 Wellcome Trust Centre for Human Genetics, Department of Genomics, Oxford, United States

74. CHARACTERIZATION OF THE REGULATORY MUTATION MVWF1, A MAJOR CAUSE OF PROLONGED APTTS IN MICE
Johnsen J 1, Ginsburg D 2
1 University of Michigan, Ann Arbor, United States, 2 Howard Hughes Medical Institute, Ann Arbor, United States

75. GENETICS OF GENE EXPRESSION OF THE INSULIN SIGNALING PATHWAY IN POLYGENIC OBESITY
Ferrell AD, Allan MF, Pomp D
University of Nebraska, Lincoln, United States

76. TWO NOVEL ENU-INDUCED CIRCADIAN RHYTHM MUTANTS IN MICE
Siepka SM 1, McGurk R 1, Chen M 1, Marusawa A 1, Olson D 1, Walkowiak J 1, Pinto L 1, Takahashi JS 2
1 Center for Functional Genomics, Northwestern University, Evanston, United States, 2 Howard Hughes Medical Institute, Evanston, United States

77. AN INSERTION OF A RETROTRANSPOSON IN THE EDNRB GENE CAUSES PIEBALD COAT COLOR OF THE S/S MOUSE
Ohtani S 1, Yamada T 2, Sakurai T 2, Tsuji T 1, Yanagisawa M 2, Kunieda T 1
1 Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan, 2 Howard Hughes Medical Institute, Department of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, United States

78. DOSAGE COMPENSATION BY UP-REGULATION OF X-LINKED GENES: MICROARRAY REVEALS TISSUE-SPECIFIC DIFFERENCES
Nguyen DK, Disteche C
University of Washington, Seattle, United States

79. COMPARATIVE ANALYSIS OF THE NR1I3 LOCUS BETWEEN THE APN STRAIN AND A CHROMOSOME 1 APN.C3H/HEJ CONGENIC STRAIN WITH AN ALTERED DRUG METABOLISM PHENOTYPE
Casley WL, Le Blanc CA, Lavigne L, Nowakowska M
Health Canada, Ottawa, Canada

80. IMPROVING EFFICIENCY OF TRANSGENIC RAT PRODUCTION
Filipiak WE, Saunders TL
University of Michigan Transgenic Core Facility, Ann Arbor, United States

81. RECIPROCATING WNT- AND BMP-DEPENDENT PATHWAYS DRIVE CARDIOGENESIS IN P19CL6 CELLS
Chen M 2, Asakura M 1, Nakamura T 1, Inoue H 1, Schneider M 1
1 Baylor College of Medicine, Houston, United States, 2 Agilent Technologies, Palo Alto, United States

82. EPIGENETIC EVENTS INFLUENCE THE VARIATION IN INBRED MOUSE STRAIN INNATE IMMUNE RESPONSES
Wells CA 1, Aung H 1, Himes R 1, Forrest A 1, Ravasi T 1, Grimmond S 1, Kasukawa T 2, Carninci P 2, Hayashizaki Y 3, Hume D 1
1 IMB, University of QLD, Brisbane, Australia, 2 RIKEN Genome Sciences, Wako, Japan,
 3 RIKEN Genome Sciences, Yokohama, Japan

83. DEVELOPMENT OF A WHOLE MOUSE GENOME MICROARRAY WITH EMPIRICALLY OPTIMIZED 60-MER OLIGONUCLEOTIDE PROBES USING AGILENT’S SUREPRINT TECHNOLOGY
Collins PJ, Sun H, Gao J, Nguyen K, Lin E, Doan TB, Giles S, Tang S, Fulmer-Smentek SB, Shannon KW, Webb PG
Agilent Technologies, Inc., Palo Alto, United States

84. THE MOUSE PANCCHIP: HIGH THROUGHPUT GENE EXPRESSION ANALYSIS OF THE ENDOCRINE PANCREAS
Mazzarelli J 1, White P 1, Gorski R 1, Brestelli J 1, Arsenlis A 1, Manduchi E 1, Katokhin A 2, Belova O 2, Bogdanova V 2, Elisafenko E 2, Gubina M 2, Nizolenko L 2, Perelman P 2, Puzakov M 2, Shilov A 2, Trifonoff V 2, Vorobjeva N 2, Voronin D 2, Zykov I 2, Kolchanov N 2, Kaestner K 1, Stoeckert C 1
1 University of Pennsylvania, Philadelphia, United States, 2 Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

85. Functional Annotation of Human Genes by Gene-Driven ENU Mutagenesis in Mice
Michaud EJ 1,2, Culiat CT 1,2, Barker G 1, Cain KT 1, Carpenter DJ 1, Easter LL 1, Foster CM 1, Gardner AW 1, Geiger J 3, Guo ZY 3, Houser KY 1, Hughes LA 1, Kerley MK 1, Klebig ML 1,2, Liu Z 3, Olszewski RE 1, Pinn I 1, Shaw GD 1, Shinpock SG 1, Wymore AM 1, Johnson DK 1,2, Rinchik EM 1,2,4  - 1 Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States 2The University of Tennessee–Oak Ridge National Laboratory Graduate School of Genome Science and Technology, Oak Ridge, TN; United States, 3SpectruMedix, PA, United States 4Department of Biochemistry, Cellular, and Molecular Biology, The University of Tennessee, Knoxville, TN, United States

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