International Mammalian Genome Society


The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

A1 Identifying the Role of Elements Lying in the Xic in the Control of Xist Expression, Counting and the Choice of X Chromosome to Inactivate

Philip Avner, Danielle Arnaud, Corinne Chureau, Philippe Clerc, Emmanuel Debrand, Edith Heard, Celine Morey and Marine Prissette. Unité de Génétique Moléculaire Murine, URA CNRS 1947, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France

The X-inactivation centre (Xic) is a cis acting element which controls X-chromosome counting, the choice of X chromosome to inactivate and the initiation and propagation of silencing along the length of the X chromosome. Recent experiments have provided clear evidence for the presence of a series of functional elements lying 3' to Xist which influence the basal levels of Xist expression from in undifferentiated ES cells, the counting process and the choice of X chromosome to inactivate. These elements include the Xce locus. It seems likely that elements involved in the X-inactivation process extend a considerable distance both upstream and downstream of Xist itself. An overview of some of evidence for multiple genetic elements interacting with Xist will be presented within the wider context of divergent interpretations as to the extent of the critical region necessary for Xic activity.

 


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