International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

E29 Body Weight, Food, Water and Salt Consumption in 28 Mouse Strains

A. A. Bachmanov, M. G. Tordoff, and G. K. Beauchamp. Monell Chemical Senses Center, Philadelphia, PA, 19104

The goal of this study was to characterize genetic variation in feeding behavior and body weight among mouse strains. Male 129/J, A/J, AKR/J, BALB/cByJ, BUB/BnJ, C3H/HeJ, C57BL/6J, C57L/J, CBA/J, CE/J, DBA/2J, FVB/NJ, I/LnJ, KK/H1J, LP/J, NOD/LtJ, NZB/B1NJ, P/J, PL/J, RBF/DnJ, RF/J, RIIIS/J, SJL/J, SM/J, SWR/J, SEA/GnJ, CAST/Ei and SPRET/Ei mice (n = 6 - 12 per strain) were obtained from The Jackson Laboratory and caged individually. There was more than a two-fold inter-strain variation in body weight (SPRET/Ei, 12.00.2 g vs. KK/H1J, 33.21.0 g), intake of pelleted chow (SPRET /Ei, 3.10.1 g vs. RBF/DnJ, 6.30.3 g), and water intake (RIIIS/J, 3.90.2 ml vs. SEA/GnJ, 8.20.3 ml). Solutions of NaCl (75 - 450 mM), KCl (10 - 300 mM) and CaCl2 (3 - 100 mM) were tested using 48-h two-bottle tests, with one drinking tube containing a salt solution, and the other tube containing water. The mouse strains displayed a wide range of NaCl acceptance. The CBA/J, C3H/HeJ and AKR/J mice had the strongest NaCl avoidance. The CAST/Ei mice had the strongest preference for dilute NaCl solutions, and the NZB/B1NJ and SJL/J mice had the highest acceptance of more concentrated NaCl solutions. The C57BL/6J mice had much higher KCl acceptance than did all other strains, whereas the AKR/J, BUB/BnJ and C3H/HeJ mice were on the lower end of the strain distribution. Mice from the 129/J, LP/J, C3H/HeJ and BUB/BnJ strains had higher CaCl2 preferences than did most other strains; the CE/J and KK/H1J mice had lower preferences than did most other strains. Body weight, food and water intakes were interrelated among the strains. However there was no correlation among preferences for the three salts, suggesting distinct genetic controls of sodium, potassium and calcium intake. This study demonstrates large strain variations in the consumption of food, water and several salts by mice. This variation may be associated with predispositions toward metabolic, renal, cardiovascular, neurological or endocrine diseases. The strain differences described here provide preliminary information necessary for positional cloning of underlying genes and for designing mutagenesis screens.

Supported by NIH grants R03DC03853 (A.A.B.), R01DK40099 (M.G.T.) and R01DC00882 (G.K.B.).


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