International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

H4 FESA: The Frozen Embryo and Sperm Archive at MRC Harwell, UK

Peter Glenister and Claire Thornton. Medical Research Council, Mammalian Genetics Unit, Harwell, OX11 0RD, UK

FESA provides a secure and economical means of storing the enormous numbers of new mutations generated during large ENU mutagenesis programmes. The explosion of new transgenic and other genetically manipulated lines necessitates the provision of central, securely funded archives to ensure that these resources are not lost to future researchers.

At Harwell, FESA already contains >250,000 frozen embryos from almost 1000 stocks. We now offer a free service for cryopreservation, storage and promotion of mouse embryos or sperm. Charges are levied for withdrawals from the archive.

Sperm are routinely frozen from all (C3H/HeH x BALB/c)F1 males produced in the Harwell mutagenesis programme. To date (July 1999), sperm have been archived from ~1000 males for future genotype driven screens. We have shown that several thousand offspring can be generated from the frozen sperm of a single male of this particular genotype.

FESA is one of five nodes that constitute EMMA (European Mouse Mutant Archive) and acts as the central UK repository for deposition and distribution of mouse mutants and stocks that are essential to today's genetic research.


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