International Mammalian Genome Society


The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

H5 News From the Large Scale Munich-ENU-Mutagenesis Project

Helmut Fuchs*, Dian Soewarto*, Christiane Fella*, Birgit Rathkolb#, Walter Pargent,* Stephan Heffner*, Eckhard Wolf#, Rudi Balling* and Martin Hrabé de Angelis*. *GSF Research Center, Institute for Mammalian Genetics, 85764 Neuherberg, Germany #LMU, Institut für Molekulare Tierzucht und Haustiergenetik, 81375 München, Germany

Mutants are the most important tool to obtain insight into biological function of genes. Due to the similarity in genomes, developmental, biochemical and physiological pathways, the mouse has become the model of choice for the study of inherited diseases in man. We have established a research center that carries out a large scale ENU-mouse mutagenesis screen. A number of participating research groups screen the mice for specific abnormalities, i.e. congenital malformations, clinical-biochemical alterations, immunological defects and complex traits. Emphasis is on phenotypes that are relevant for the pathogenesis of human diseases. Base line levels for the selected parameters/phenotypes have been established for C3HeB/FeJ and C57BL/6JIco mice. Over 170 mutant lines have been already isolated and are in the process of further characterization. The mutant lines are analyzed by backcross mapping and genome wide microsatellite typing in order to chromosomally map the mutations. Conserved synteny between mouse and human genome are used to check for the potential homologous human disease. Several lines are currently used in the scientific community for further analysis of gene function.

 


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