International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

E19 Characterization of Behavioral Diversity in the Inbred Strains Established from Wild Mice

Tsuyoshi Koide1,3, Kazuo Moriwaki2 and Toshihiko Shiroishi1. 1National Institute of Genetics, Mishima, Shizuoka-ken, 411-8540 Japan; 2Graduate University of Advanced Studies, Hayama, Kanagawa-ken; 3PRESTO, Japan Science and Technology Corporation

Behavior of mouse has been studied from many aspects, but, using only small numbers of laboratory strains. These mice have been domesticated in the course of being established as laboratory strains. In addition to this, it is reported that the genetic variation observed in the laboratory strains is not so large. On the other hand, wild mice behave differently comparing to laboratory mice. The inbred strains derived from wild mice (wild strains) captured in different countries, such as MSM/Ms, KJR/Ms, SWN/Ms, HMI/Ms, NJL/Ms, BFM/2Ms, BLG2/Ms and CAST/Ei are maintained in the mouse facility of the National Institute of Genetics. Since they are originated in variety of Mus musculus subspecies, diversity of behavior would be expected.

In order to characterize the behavioral pattern in the mouse strains, various aspects of behavior such as locomotor activity, emotion, and memory have been studied for eight wild strains, one fancy mouse-derived strain JF1/Ms, and two laboratory strains, C57BL/6J and DBA/1J. The result has shown that the wild strains exhibit diversity of behavioral pattern and useful for studying mouse behavior using genetic methods. We have found that KJR/Ms and NJL/Ms are the hyperactive strains contrast to four hypoactive strains, BFM/2Ms, BLG/2Ms, HMI/Ms and JF1/Ms. Furthermore, two strains, KJR/Ms and SWN/Ms are the good learner contrast to BLG2/Ms which show impaired learning ability in both of passive and active avoidance tests. This diversity of behavioral pattern observed in wild strains will allow genetic study of these behavioral traits. We are currently trying to map genes responsible for these behavioral phenotypes.


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