International Mammalian Genome Society


The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

E23 High-Resolution Mapping of QTL for Body Weight in Mice by Progeny Testing

Xiaojun Liu and Peter Keightley, Institute of Cell, Animal and Population Biology, University of Edinburgh West Mains Road, Edinburgh EH9 3JT, Scotland, UK

Previous studies of the genetic differences between mouse lines selected for growth rate have shown evidence for a large X-chromosome effect accounting for approximately 25% of the divergence between the lines. And further QTL mapping experiments suggest that almost all of the X-linked difference in body weight is associated with a single QTL located between the mirosatellite markers DXMit226 and DXMit68, which are about 3 cM apart, at the proximal end of the chromosome. Since mapping to a sub-cM level is required to positionally clon any genes, additional markers are needed to be found in the region. We describe results from a progeny testing approach to high-resolution mapping at which positional cloning of QTLs in mammals is feasible.

 


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