International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

B6 The Mouse Tumor Biology Database (MTB) Project

Cathleen M. Lutz, Debra M. Krupke, Carol J. Bult, John P. Sundberg, Janan T. Eppig. The Jackson Laboratory, Bar Harbor, Maine

The Mouse Tumor Biology Database (MTB) is designed to support the use of the mouse as a model system of hereditary and induced cancers. This online resource provides cancer researchers with access to data regarding various mouse models for cancer including such information as tumor names and classifications, tumor incidence and latency data in different strains of mice, tumor pathology reports and images, information on genetic factors associated with tumors and tumor development, and references (for both published and unpublished data).

By making such data readily available via web-based forms MTB provides the scientific community with a much-needed, easily accessible central resource for scanning and searching the rapidly expanding volume of mouse tumor data previously only accessible in various scattered resources, either in electronic or hardcopy form. The MTB database is designed to facilitate the choosing of experimental models for cancer research, assessing mouse genetic models of human disease, reviewing of patterns of mutations in specific cancers, and identifying of genes that are commonly mutated across a spectrum of cancers.

A prototype of the MTB database is currently available via the World Wide Web at User support is available for MTB via e-mail to Hypertext links are provided from MTB to the Mouse Genome Database (MGD) for added information regarding mouse genes and to the JAX Mice database for further information regarding strains of mice available from The Jackson Laboratory. Future plans for the MTB database include further integration with the current Mouse Genome Informatics (MGI) databases and the facilitation of direct electronic submission of mouse tumor data from the scientific community.

This project is funded by the National Cancer Institute of NIH, contract #97CSX022A.


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