International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

Table of Contents * Structure * Bioinformatics * Sequence * Mapping * New Tools * Gene Discovery * Developmental * Mutagenesis * Functional Genomics

F47 Genetic and Physical Mapping of Hague (Hag), A Mouse Hair Mutation with Unusual Transmission

Christophe Poirier, Atsushi Yoshiki, and Moriaki Kusakabe. Division of Experimental Animal Research, Institute of Physical and Chemical Research (RIKEN), Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, JAPAN

In course of breeding, a mouse with curly whiskers and wavy hairs was found in a C3H/HeN stock. From this mouse we have started a new colony in a C3H/HeN genetical background. A more severe hair phenotype was observed in this colony, these mice have extremely curled hairs and begin to lose body hairs from 2 weeks of age, by 3 weeks they have completely lost the first hair coat. Therefore in this colony 3 phenotypes were segregated: wild type, phenotype 1 (original abnormal phenotype) and phenotype 2 (severe phenotype). This mutation has been kept in 2 isogenic C3H/HeN colonies, one by mating phenotype 2 mice (BARE colony) and the other by mating phenotype 1 mice (WAVY colony).

The number of genes involved and their status of transmission have been determined and a high resolution genetic map have been constructed around this locus. This locus have been mapped to the keratin genes complex on mouse chromosome 15 and the corresponding physical map in YAC was constructed.


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