International Mammalian Genome Society

The 13th International Mouse Genome Conference
October 31-November 3, 1999

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E55 Mapping of Seizure-Related (SEZ) Genes and an Approach to Identify the PTZ Susceptibility Loci in Mice

Shigeharu Wakana1,5, Norikazu Yokete2, Fumiki Naramoto2, Kagemasa Kajiwara3, Tadashi Tsuda2, Hiromi OhguchiH2, Aiko Sugaya2, Chika Maruyama1, Tatsuji Nomura1, and Eiichi Sugaya4. 1Central Institute for Experimental Animals, Kawasaki 216-0001 Japan; 2Faculty of Pharmacology, Josai University, Sakado 350-0295 Japan; 3Institute of Medical Science, Tokai University, Isehara 259-1193 Japan; 4Tokyo Hospital, Tokai University, Tokyo 151-0053; 5Mouse Functional Genomics Research Group, RIKEN Genomic Science Center, Yokohama, 224-0804 Japan

The SEZ (seizure-related) group genes are identified by differential display screening using pentylenetetrazol (PTZ)-treated cultured neurons and cultured normal neurons from cerebral cortex of C57BL/6 mice. In order to map the loci of the novel SEZ genes, we performed linkage analysis of 9 main SEZ genes. On the other hand, we examined strain difference of sensitivity to the PTZ-induced convulsions. Since DBA/2J is highly susceptible to convulsions and C57BL/6J and MSM belong to a high threshold group with respect to convulsions, the QTL analysis of PTZ-induced seizure sensitive loci was carried out using the crosses of BXD RI strains and (C57BL/6J x DBA/2J ) F2. Comparison of the SEZ loci with PTZ susceptive loci is under progress, which would provide some clues to understand the molecular mechanism of epileptic seizures.


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