International Mammalian Genome Society

The 14th International Mouse Genome Conference (2000)

Table of Contents * Genes, Physical Mapping and Sequencing * Gene Identification * Bioinformatics * Common Resources * RIKEN Session * Functional Genomics * Complex Traits * Mutagenesis * Developmental Genetics and Differentiation * Verne Chapman Memorial Lecture I and II

C14. FANTOM+: Web Interface for the Functional Annotation of Mouse

Hidemasa Bono¹, Takeya Kasukawa^1,2, Katsunaga Sakai¹, Masaaki Furuno¹, Toshihisa Okido¹, Shotaro Kohtsuki², Kiyoshi Yoshida¹, Yasushi Okazaki¹ and Yoshihide Hayashizaki^1,3
1Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC) and Genome Science Laboratory, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan,
²Multimedia Development Center, Advanced Technology Development Department, NTT Software Corporation, 223-1 Yamashita-Cho, Naka-ku, Yokohama-shi, Kanagawa 231-8554, Japan,
³Core Research of Evolutional Science and Technology (CREST)

In order to annotate the function of approximately 20,000 full-length mouse cDNAs sequenced in RIKEN, we held the FANTOM (Functional ANnoTation Of Mouse) meeting through 28th August to 8th September. This meeting was also aimed to discuss and establish the international standard of such annotations.

We have developed web-based system, named FANTOM+, for annotating functional information of all clones to be facilitated for functional annotation by human effort in the meeting. FANTOM+ does not only include the gene function itself, but many other informative data describing functional information of the gene. These include supplemental descriptions of gene function(gene symbol and its synonym), the functional classification(Gene Ontology, and TIGR EGAD), chromosomal localization(from genetic mapping and physical mapping if available), expression specificity(organ localization and sub-cellular localization of cDNA), mutation information(disease and knockout mouse information), and the publications.

Main features of the FANTOM+ system are

1. Simply described in HTML and Javascript capable of heavy use in the meeting

2. GUI (Graphical User Interface) enables minimal use of keyboard

3. History administration system to trace back the previous annotation

These data of gene annotations are distributed in XML format, in addition to be viewed safely through encrypted web server(Policy Director) via SSL using typical web browser.

Acknowledgement

We thank Hideo Aono¹ for his contribution to develop our web-based system and to annotate functional information.