International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)

Table of Contents * Complex Genetics * Developmental Genetics * Gene Annotation * Gene Discovery * Genome Sequencing * Functional Genomics * Mutagenesis * Presentations * Verne Chapman Memorial Lecture

Soline Vigneau
Institut Pasteur
Unité des Virus Lents
28, rue du Dr Roux
75724 Paris cedex 15
France

Co-Authors: 1)Florence Levillayer, 2)Hervé Crespeau, 2)Laurence Cattolico, 3)Bernard Caudron, 1)Franck Bihl, 2)Catherine Robert, 1)Michel Brahic, 2)Jean Weissenbach, 1)Jean-François Bureau
Institutions: 1)Unité des Virus Lents (CNRS URA 1930), 2)Genoscope (Centre National de Séquençage), 3)Service d'Informatique Scientifique, Institut Pasteur,

As comparative sequence analysis between the human and mouse genomes is an attractive tool for genome annotation, a mouse 173 kb region telomeric to the Ifng locus on chromosome 10 was sequenced and compared by various sequence analysis programs to the human homologous sequence located on chromosome 12q15. This region has a low density of genes: one gene was detected in the mouse as well as the human sequences and a second one only in the human sequence. The mouse gene and its human ortholog, which are expressed in the immune system at low level, produce a non-coding mRNA. Surprinsingly, non-expressed sequences show higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow).