International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)

Plenary Presentations * Oral Presentations *
Poster Presentations: Complex Genetics and Disease Modifiers * Developmental Genetics * Functional Genomics * Gene Discovery * Genetic Manipulations to Alter Gene Function * Mouse Models: Human Disease and Pharmacogenetics * Sequence Annotation and Comparative Analysis of Genomes *
Attendees * Sponsors * Table of Contents * Photographs * Awards

POSTER 150 - MAPPING OF NEW QUANTITATIVE TRAIT LOCI (QTL) RESISTANCE TO MALARIA IN MICE BY A COMPARATIVE APPROACH OF HUMAN CHROMOSOME 5q31-q33

M Hernandez-Valladares
International Livestock Research Institute (ILRI) and Institute of Molecular and Cell Biology-Africa (IMCB-A)

1) ole-MoiYoi OK, 2) Iraqi F
1) Institute of Molecular and Cell Biology-Africa (IMCB-A) (Kenya), 2) International Livestock Research Institute (ILRI)

Human malaria remains a major cause of mortality in many tropical countries, mainly those in sub-Saharan Africa. A recent review has concluded that about 1 million deaths occur yearly, more than 75% of them in children. Human genetic responses to malaria infection are not well understood, but need to be better studied, if successful strategies for control of malaria are to be realized.These complex traits can be more easily dissected in genetically well-defined inbred mouse strains. Among the murine malaria models, Plasmodium chabaudi provides a valuable experimental model of the human disease, with many similarities to Plasmodium falciparum infection. In the last few years, several studies in backcross and F2 populations as well as in recombinant congenic strains infected with Plasmodium chabaudi, have located a number of susceptibility loci on chromosomes 3, 8, 9 and 17.Recently, we have developed a F11 advanced intercross line (AIL) population of C57Bl/6xA/J mice. Genetic analyses of F11 AIL mice have confirmed the previous mapped QTL on chromosomes 8 and 17, within a narrower genomic region. The same population of mice has been used to search for additional QTL on chromosome 11 and 18 by a comparative mapping approach of human chromosome 5q31-q33, a region linked to Plasmodium falciparum blood infection levels.