International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)

Plenary Presentations * Oral Presentations *
Poster Presentations: Complex Genetics and Disease Modifiers * Developmental Genetics * Functional Genomics * Gene Discovery * Genetic Manipulations to Alter Gene Function * Mouse Models: Human Disease and Pharmacogenetics * Sequence Annotation and Comparative Analysis of Genomes *
Attendees * Sponsors * Table of Contents * Photographs * Awards

Oral Presentation

Monday 18 November

20:45 - 21:00 HRS

X-INACTIVATION MEDIATES AN EFFECT ON MATERNAL RECOMBINATION AND MEIOTIC DRIVE

E. de la Casa-Esperon
Temple University School of Medicine

Co-Authors: 1) Loredo-Osti J C, 2) Pardo-Manuel de Villena F, 4) Briscoe T L, 5) Malette J M, 6) Vaughan J E, 1) Morgan K, 8) Sapienza C
Institutions: 1) McGill University, 2) University of North Carolina F, 4) Temple University School of Medicine, 5) Temple University School of Medicine, 6) Temple University School of Medicine, 7) McGill University, 8) Temple University School of Medicine

Crosses between the DDK inbred mouse strain and other inbred strains and their F1 hybrids show two interesting phenomena: early embryonic lethality (“DDK syndrome”) and preferential segregation of chromosomes during female meiosis (meiotic drive at the second meiotic division). Components of both phenotypes have been mapped to the central region of chromosome 11. We now observe a third phenomenon: overall levels of meiotic recombination differ between females of identical (C57BL/6-Pgk1a x DDK)F1 genotype, and this variability correlates with their pattern of X-inactivation. Because meiotic drive is affected by recombination, a correlation is also observed between the levels of transmission ratio distortion at chromosome 11 and the patterns of X-inactivation of the F1 females. Our results indicate the presence of a locus/loci on the X chromosome that is involved in the control of recombination. This locus/loci is subject to X-inactivation and the expression of different alleles results in differences in levels of genome-wide recombination.