International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany

Plenary Presentations * Oral Presentations *
Poster Presentations: Behavioural Genetics and Genomics * Development and Stem Cells * Functional Genome Analysis * Mouse Models of Human Disease * Mouse System Biology Bioinformatics * Multigenic and Multifactorial Trait Analysis * Nutrition and Metabolic Disease * Phenotyping Methods Imaging * The Genetics and Genomics of Infectious Disease *
Verne Chapman Memorial Lecture * Table of Contents * Sponsor/Exhibitor List * Awards * Photographs

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PLENARY PRESENTATION

MONDAY 10 NOVEMBER
09:00 – 09:30 HRS

NEW RESEARCH INITIATIVES AT THE JACKSON LABORATORY

Richard P Woychik
The Jackson Laboratory

Co-Authors: Scientific Staff
Institutions: The Jackson Laboratory

There has been remarkable progress over the past several years in using the mouse as a model for studying human biology and disease. New protocols and technologies for mutagenesis have accelerated the pace of generating mutant lines with Mendelian traits in the mouse. Additionally, access to the human genome sequence, the draft sequence of the mouse, an increasing number of mapped SNP's, and powerful new bioinformatics data bases and computational tools have vastly improved our ability to analyze complex traits in the mouse. New initiatives at The Jackson Laboratory are focusing on improved gene localization, and cloning of genes responsible for phenotypic deviation in mice. These initiatives are built on the experience gained with the phenotyping of mice from our ENU mutagenesis programs and from the Phenome Project, which compares specific phenotypes of mice from inbred strains. We expect the challenge to identify new phenotypes in mice will happen through the development of new technologies at the Institute of Molecular Biophysics, developed together with the University of Maine and based at The Jackson Laboratory.