International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany

Plenary Presentations * Oral Presentations *
Poster Presentations: Behavioural Genetics and Genomics * Development and Stem Cells * Functional Genome Analysis * Mouse Models of Human Disease * Mouse System Biology Bioinformatics * Multigenic and Multifactorial Trait Analysis * Nutrition and Metabolic Disease * Phenotyping Methods Imaging * The Genetics and Genomics of Infectious Disease *
Verne Chapman Memorial Lecture * Table of Contents * Sponsor/Exhibitor List * Awards * Photographs

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ORAL PRESENTATION

WEDNESDAY 12 NOVEMBER
15:00 – 15:15 HRS

MAKING SENSE OF SEQUENCE: INTEGRATING BIOLOGICAL KNOWLEDGE WITH THE MOUSE GENOME

Bult CJ
The Jackson Laboratory

Co-Authors: Bradt D, Reed D, Zhu S, Qi D, Sinclair B, Blake J A, Ringwald M, Eppig JT, Richardson J E, Kadin J A, The Mouse Genome Informatics Group.
Institutions: The Jackson Laboratory

The release of the publicly accessible mouse genome sequence for the C57BL/6J strain of the laboratory mouse represents a landmark event in genome biology. The ability of researchers to use the mouse genome sequence effectively will depend, in large part, on how well the genes and other features identified in the sequence are integrated with the biological data sets available for the mouse that are available from the Mouse Genome Informatics (MGI) database. Model organism databases, such as MGI, have a unique role to play in connecting sequence and biology and in curating these connections for the long term.

The ways in which sequence data are stored and subsequently accessed from MGI are changing rapidly. Results of these significant enhancements to the capacity of the database will better enable the mouse genetics and genomics research communities to find biological meaning in the mouse genome sequence. I will present the status of our sequence-to-biology integration efforts, highlight the pending changes in the MGI user interfaces to enhance access to sequence data, and discuss the results of an analysis we have performed for incorporating the rapidly emerging publicly available mouse Single Nucleotide Polymorphism (SNP) data sets into MGI.

MGI is available at: http://www.informatics.jax.org. MGI funding support comes from NIH grants HG00330, HG02273, CA89713 and HD33745.