International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany

Plenary Presentations * Oral Presentations *
Poster Presentations: Behavioural Genetics and Genomics * Development and Stem Cells * Functional Genome Analysis * Mouse Models of Human Disease * Mouse System Biology Bioinformatics * Multigenic and Multifactorial Trait Analysis * Nutrition and Metabolic Disease * Phenotyping Methods Imaging * The Genetics and Genomics of Infectious Disease *
Verne Chapman Memorial Lecture * Table of Contents * Sponsor/Exhibitor List * Awards * Photographs

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POSTER 12 - CHARACTERIZATION OF EXPRESSION DIFFERENCES IN WAVED 3 MICE THAT LEAD TO ABNORMAL HEART AND SKIN DEVELOPMENT

Herron B
1) Wadsworth Center NYS DOH, 2) SUNY Albany

Co-Authors: 2) Oliveri E, 1) Parker A, 1) Kinne J, 4) Lien E, 4) Olsen E, 3) Beier D
Institutions: 1) Wadsworth Center NYS DOH, 2) SUNY Albany, 3) Harvard Medical School, 4) UT South-western Medical school

We are characterizing a novel mouse phenotype that is due to a mutation in Nfkb/Nkx interacting protein 1 (Nkip1). Waved 3 (wa3) mice are phenotypically similar to wa1 and wa2 mice, but also have a progressive and ultimately lethal form of dilated cardiomyopathy. Nkip1 has been shown to interact with several transcription factors including the RelA subunit of NFkB and Nkx2-5. Nkip1 is thought to repress the activity of these proteins; however, this function has only been investigated through in vitro studies. To identify what transcriptional networks are abnormal in wa3/wa3 mice, and ultimately find genes that are direct targets of Nkip1, we are surveying expression of genes previously shown to be targets of NFkB and Nkx2.5 transcriptional activity. We are also generating expression profiles on heart and skin RNA from normal and wa3/wa3 mice. This data will extend our understanding of the molecular pathogenesis of dilated cardiomyopathy and help identify the pathways that contribute to the wa3 phenotype.