International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany

Plenary Presentations * Oral Presentations *
Poster Presentations: Behavioural Genetics and Genomics * Development and Stem Cells * Functional Genome Analysis * Mouse Models of Human Disease * Mouse System Biology Bioinformatics * Multigenic and Multifactorial Trait Analysis * Nutrition and Metabolic Disease * Phenotyping Methods Imaging * The Genetics and Genomics of Infectious Disease *
Verne Chapman Memorial Lecture * Table of Contents * Sponsor/Exhibitor List * Awards * Photographs

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Functional Genome Analysis

POSTER ABSTRACTS
POSTERS 23 - 72

23. CONTRIBUTION OF JAPANESE WILD MICE, MUS MUSCULUS MOLOSSINUS, TO GENOME CONSTITUTION OF C57BL/6 STRAIN
Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T

24. VELOCIGENE: A HIGH-THROUGHPUT APPROACH FOR GENOME ENGINEERING, ASSIGNMENT OF GENE FUNCTION AND HIGH-RESOLUTION EXPRESSION ANALYSIS IN MICE
Adams N C, Economides A N, Murphy A J, Kraus P, Gale N W, Auerbach W, Frendewey D, DeChiara T M, Valenzuela D M, Yancopoulos G D

25. DOES OVEREXPRESSION OF THE IMPRINTED GENE NEURONATIN CAUSE A REDUCTION IN PITUITARY SIZE AND GROWTH HORMONE CELL NUMBERS?
Beechey C V, Peters J, Skinner J, Christian H, Fischer-Colbrie R

26. GENETIC MAPPING AND ANALYSIS OF HEAD SLANT (hslt), A NOVEL VESTIBULAR MUTANT WITH COMPLETE ABSENCE OF OTOCONIA
Bergstrom D, Gagnon L, Bergstrom R, Schimenti J, Johnson K

27. THE ULTIMATE™ ORF BROWSER: ADVANCED SEARCH TOOL AND INFORMATION CENTER FOR THE ULTIMATE™ ORF CLONE COLLECTION
Parvizi B, Yen J, Liang F, Boyaniwsky T

28. CAP ANALYSIS GENE EXPRESSION (CAGE) FOR HIGH THROUGHPUT ANALYSIS OF TRANSCRIPTIONAL STARING POINT AND IDENTIFICATION OF PROMOTER USAGE
Carninci P, 1, Shiraki T, Kondo S, Katayama S, 1, Waki K, Kasukawa T, Kawaji H, Nakamura M, 1, Kodzius R, Arakawa T, Fukuda S, Sasaki D, Podhajska A, Kawai J, and 1, Hayashizaki Y

29. REGION SPECIFIC ENU MUTAGENESIS ON MOUSE CHROMOSOME 5
Ching Y, Wilson L, Howell G, Hartford S, Sears A, Schimenti J

30. FAST EVOLUTION OF THE MOUSE SEX CHROMOSOMES
Disteche C, Nguyen D K

31. A SENSITIZED ENU MUTAGENESIS SCREEN IN ANIMAL MODELS OF CHRONIC INFLAMMATORY DISEASES AS A TOOL FOR DRUG TARGET DISCOVERY
Douni E, Sekara E, Kamber M, Mantellou M, Kontoyiannis D, Kollias G

32. AN EXPRESSION GENE TRAP MUTAGENESIS RESOURCE AT THE CENTRE FOR MODELING HUMAN DISEASE (CMHD)
Epp T, Reid T, Hant P, Lan Q, Li C, Ohishi M, To C, Tsao N, Yu M, Kassam N, Osborne L, Rossant J, Stanford W

33. FUNCTIONAL ANALYSIS OF THE MAMMALIAN GENOME REVEALS NOVEL THERAPEUTIC ENTRY POINTS FOR HUMAN DISEASE
Grosse J, Stumm G, Laufs J, Augustin M, Sedlmayer R, Wattler S, Nehls M C

34. MAINTENANCE OF PARALOGS THROUGH SHUFFLING OF UPSTREAM REGULATORY SEQUENCES
Hafner M

35. NEUROPILIN-1: A SURFACE MARKER OF REGULATORY T CELLS
Hansen W, Bruder D, Probst-Kepper M, Westendorf A Geffers R von Boehmer H Buer J

36. IDENTIFICATION OF GENOMIC SITES OF TISSUE SPECIFIC DNA METHYLATION USING REAL AND VIRTUAL RESTRICTION LANDMARK GENOMIC SCANNING
Song F, Kimura MT Smith J Matsuyama T, Nagase H Held W A

37. CHEMICAL MUTAGENESIS OF MOUSE EMBRYONIC STEM CELLS
Greber B, Lehrach H, Himmelbauer H

38. COMMON AND DISTINCT EXPRESSION PATTERNS OF THE IGF-SYSTEM IN MICE IN RESPONSE TO DIVERGENT GROWTH SELECTION
Hoeflich A, Bünger L, Nedbal S, Renne U, Elmlinger M W, Blum W F, Bruley C, Kolb H J, Wolf E

39. IDENTIFICATION OF TUMOUR-ASSOCIATED GENES IN THE PROCESS OF MURINE SKIN CARCINOGENESIS
Hummerich L, Müller R, Wrobel G, Kokocinski F, Gack S, Schorpp-Kistner M, Fürstenberger G, Hess J, Hahn M, Angel P, Lichter P

40. PHYSICAL LINKAGE OF SIMILARLY REGULATED GENES AND CONTEXT-DEPENDENT REGULATION ON RIBOSOMAL PROTEIN GENES
Wahl M, Imai K

41. DEVELOPMENT OF THE FINE HISTOLOGICAL GENE EXPRESSION MAP FOR THE FUNCTIONAL GENOME ANALYSIS
Kusakabe M, Inoue J, Aotsuka S, Inoue T, Matsuba K

42. ANALYSIS OF ENU MUTAGENESIS-DERIVED MUTANTS WITH ABNORMAL LIMB DEVELOPMENT
Masuya H, Toki H, Shimizu A, Nagano J, Gondo Y, Wakana S, Noda T, Shiroishi T

43. MAPPING MUTATIONS ARISING FROM A LETHAL RECESSIVE SCREEN WITHIN THE Del(13)Svea36H REGION OF MOUSE CHROMOSOME 13
McKeone R, Southwell A, Cadman M, Arkell R, Davies J, Bogani D, Mallon A, Weekes J, Denny P, MRC Harwell

44. TOWARDS A COMPARATIVE PROTEOME/TRANSCRIPTOME ANALYSIS OF GENES EXPRESSED IN LIVER AND KIDNEY OF THE MOUSE
Mijalski T, Drobyshev A, Horsch M, Schädler S, Halder T, Harder A, Lottspeich L, Hrabe de Angelis M, JBeckers B

45. EMBRYONIC EXPRESSION OF Raidd USING β-gal REPORTER GENE IN TRANSGENIC MICE
Motaln H, McWhir J, Horvat S

46. ENHANCER FUNCTION IN THE MELANOCYTE LINEAGE
Murisier F, Guichard S, Beermann F

47. PHYSICAL MAP AND SEQUENCE ANALYSIS IN MOUSE T-COMPLEX
Nagaraja R, Brathwaite M, Waeltz P, Schroeder M, Jefferson J, Schein J, Marra M, Abe K and Roe B.

48. MOUSE BAC CGH ARRAY TO IDENTIFY GERM-LINE MUTATIONS INDUCED BY HEAVY ION BEAM (HIB) IRRADIATION
Kimura MT, Conroy JM, Nowak N, Igarashi J, Yoshiki A, Kusakabe M, Nagase H

49. BIODOSIMETRY BY DETECTING Γ-H2AX FOCI IN CB.17 MOUSE PERIPHERAL LYMPHOCYTES, ORGAN TISSUES AND SCID LYMPHOMA CELLS AFTER ¹³⁷CS Γ-RAY IRRADIATION
Nakajima H, Tsuboi R, Nomura T

50. A DATABASE COMPARING DIFFERENTIAL EXPRESSION WITH HALLMARKS OF IMPRINTED GENES
Oakey R J, Underkoffler L A, Collins J N, Beechey C V, Choi J D

51. COMPARATIVE AND FUNCTIONAL CHARACTERIZATION OF THE PHR1 LOCUS
Peterson K, Burgess R, Johnson M, Roix J, Welsh I, O'Brien T

52. LARGE-SCALE IDENTIFICATION AND MAPPING OF NUCLEAR MATRIX-ATTACHMENT REGIONS IN THE DISTAL IMPRINTED DOMAIN OF MOUSE CHROMOSOME 7
Purbowasito W, Suda C, Yokomine T, Zubair M, Sado T, Tsutsui K, Sasaki H

53. NGFN XPRESS: GENOME-WIDE RNA EXPRESSION ANALYSIS OF MOUSE MODELS WITHIN THE NATIONAL GENOME RESEARCH NETWORK
Rieger S, Drobyshev A, Schulz H, Stöger T, Alessandrini F, Jakob T, Behrendt H, Seliger B, Graw J, Ziesenis A, Schmitt-John, Schachner M, Willnow T, Lengeling A, Hauser H, Klingenspor M, Chakraborty T, Hrabe de Angelis M, Beckers J

54. THE JUVENILE SPERMATOGONIAL DEPLETION (JSD) PHENOTYPE IS DUE TO A MUTATION WITHIN A NUCLEOLAR U3 RIBONUCLEOPROTEIN GENE REQUIRED FOR 18S RIBOSOMAL RNA BIOGENESIS
Rohozinski J, Bishop CE

55. FUNCTIONAL ANALYSIS OF THE MAMMALIAN GENOME BY LARGE SCALE GENE TRAP MUTAGENESIS
Ruiz P, Hansen J, Floss T, van Sloun P, Schnütgen F, Füchtbauer EM, Vauti F, Lehrach H, von Melchner H, and Wurst W

56. HIGH-THROUGHPUT MUTATION DISCOVERY BY MULTIPLEX TGCE (TEMPERATURE GRADIENT CAPILLARY ELECTROPHORESIS) IN MOUSE ENU-MUTAGENESIS
Sakuraba Y, Sezutsu H, Takahasi KR, Tsuchihashi K, Kaneko S, Fujimoto N, Matsumoto R, Ikeda A, Karashima Y, Inoue M, Kaneda H, Minowa O, Wakana S, Noda T, Shiroishi T, Gondo Y

57. INGENOTYPING -- HIGH SPEED GENERATION OF ALLELIC VARIANTS FOR GENE FUNCTION ANALYSIS AND TARGET VALIDATION
Sedlmeier R, Peters T, Huffstadt U, Wattler S, Nehls M

58. MOUSEEXPRESS: RNA EXPRESSION PROFILING OF ENU MOUSE MUTANTS
Seltmann M, Horsch M, Drobyshev A, Mader M, Tornow S, Frohme M, Korica T, Mewes W, Hoheisel J, Hrabe de Angelis M, Beckers J

59. DIRECTED MUTAGENESIS OF THE BROWN LOCUS ON CHROMOSOME 4 AND A HIGH THROUGHPUT SEQUENCE BASED SCREEN TO IDENTIFY MUTATIONS
Smyth I, Holdsworth A, Edgar R, White S, Taylor M, Gautier P, Justice M, Jackson I

60. The PDZ PROTEIN TIP-1 INHIBITS β-CATENIN TRANSCRIPTION ACTIVITY AND GROWTH OF COLORECTAL CANCER CELLS
Suzuki H, Kanamori M, Kai C, Hayashizaki Y, Sandy P, Marzinotto S, Benetti R, Schneider C

61. ESTABLISHMENT OF A SCREENING SYSTEM FOR MUTANTS AFFECTING GENOMIC IMPRINTING IN THE RIKEN-GSC PROJECT
Suzuki T, Furuumi H, Hashimoto M, Kaneda H, Gondo Y, Noda T, Wakana S, Ishino F, Sasaki H, Shiroishi T

62. DEVELOPMENTAL PROFILE OF DNA METHYLATION AND GENE EXPRESSION AT THE H19 LOCUS IN MICE LACKING SEQUENCE REQUIRED FOR GENOMIC IMPRINTING
Thorvaldsen J, Fedoriw A, Yang G, Nguyen S, Magnuson M, Bartolomei M

63. FINE AND DEEP HAPLOTYPE MAPPING OF CHROMOSOME 17 IN INBRED AND WILD MOUSE
Trachtulec Z, Vlcek C, Mihola O, Forejt J

64. NESPAS: THE UNRAVELLING STORY OF ITS FUNCTION IN THE GNAS IMPRINTING CLUSTER
Turner MD, Williamson C, Nottingham W, Ball S, Maconochie M, Peters J

65. MUTATION OF A NOVEL GENE IN THE MOUSE RESULTS IN REDUCTION OF BODY WEIGHT AND FAT TISSUE
Meyer N, Ruiz P, Suresh Kumar R, Arnold HH, Vauti F

66. SPROUTY4 (SPRY4) IS ESSENTIAL FOR CORRECT LIMB FORMATION
Suresh Kumar R, Vauti F, Arnold HH

67. THE MOUSE ORTHOLOG OF THE HUMAN FAC1 GENE: MOLECULAR AND FUNCTIONAL ANALYSIS OF A NOVEL GENE TRAP MOUSE LINE
Goller T, Suresh Kumar R, Ruiz P, Arnold HH, Vauti F

68. ANALYSIS OF A NEW MOUSE LINE WITH A GENE TRAP VECTOR INTEGRATION IN A KRAB ZINC-FINGER ENCODING GENE
Prochnow B R, Arnold HH, Vauti F

69. DEVELOPMENT OF ALTERNATIVE SPLICING LIBRARIES REVEALS THE COMPLEXITY OF ALTERNATIVE SPLICING IN MOUSE MELANOMA AND MELANOCYTE CELLS
Watahiki A, Shiraki T, Waki K, Kondo S, Ishizuka Y, Arakawa T, Kawai J, Hayashizaki Y, Carninci P

70. TRANSCRIPTIONAL ORGANISATION AND EXPRESSION ANALYSIS OF A NOVEL IMPRINTED GENE
Wood A J, Underkoffler L A, Collins J N, Choi J D, Beechey C V, Oakey R J.

71. DEVELOPMENTAL EXPRESSION PROFILE CHANGES OF THE ORGAN OF CORTI FROM DEAF MOUSE MUTANTS
Yang JW, Hardisty R, Varela A, Mburu P, Parkinson N, Willan J, Pritchard C, Underhill P, Hilton H, Madge J, Polley S, Carey AH, Jones H, Soares B, Brown S

72. STRUCTURAL AND FUNCTIONAL COMPARISONS BETWEEN THE IMPRINTED MASH2-IGF2-H19 REGION ON MOUSE CHROMOSOME 7 AND THE ORTHOLOGOUS REGION ON CHICKEN CHROMOSOME 5
Yokomine T, Sirohzu H, Purbowasito W, Toyoda A, Kato R, Suda C, Hori T, Tsudzuki M, Matsuda Y, Mizuno S, Hattori M, Mukai T, Sakaki Y, Sasaki H