18th International Mouse Genome Conference
17-22 October 2004, Seattle, USA
Plenary Presentations * Oral
Presentations * Poster
Abstracts * Photos
Verne Chapman Memorial Lecture * Table
of Contents * Attendees * Awards
POSTER 13 - ASSESSING GENOMIC VARIATION IN COMMON STRAINS OF INBRED MICE
Cervino ACL, Edwards S, Schadt E
rosetta/merck, seattle, United States
We characterized DNA variation in 60 different strains of mice, including 56 common strains ordered from the Jackson Laboratories. Using phylogenetic analysis we investigated how various common strains relate to each other. Insight into heterozygosity between strains and between markers is essential in the selection of both an optimal set of strains and an optimal set of markers for the experimental crosses aimed at elucidating complex phenotypes. In addition to the survey of genomic variation we also investigated a number of clinically relevant phenotypes and gene expression profiles in a subset of strains.