18th International Mouse Genome Conference
17-22 October 2004, Seattle, USA
Plenary Presentations * Oral
Presentations * Poster
Abstracts * Photos
Verne Chapman Memorial Lecture * Table
of Contents * Attendees * Awards
PROGRAM
Sunday October 17, 2004
| 9.00am –12.00pm | Secretariat Meeting |
| 11.00am–1.00pm | Student Scholar Symposium Registration |
| 2.00pm –7.00pm | Main Conference Registration |
| 1.00pm –1.05pm |
Welcome and Introduction to the Student Scholar Symposium
Ian Jackson MRC Human Genetics Unit, Edinburgh, United Kingdom |
| 1.05pm –3.17pm | Student Scholar Symposium Session I –Studies of the Mammalian Genome | |
| 1.05pm –1.17pm |
P117 - Function of Recq Dna Helicases Blm and Recql5 in
the Suppression of Mitotic Crossovers and Maintenance of Genomic
Stability
Hu Y, Barnes E, Luo G Case Western Reserve University, Cleveland, United States |
|
| 1.17pm –1.29pm |
P36 - Identification of Novel Imprinted Genes
on Mouse Chromosomes 7 and 18
Woodfine K1 , Choi JD1, Wood AJ1, Collins JN2, Oakey RJ 1 1 Division of Medical Genetics, GKT School of Medicine, London, United Kingdom, 2 Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, United States |
|
| 1.29pm –1.41pm |
P167 - Further Mapping of the Mouse Deafness
Mutant Bronx Waltzer
Taylor A1 , Cheong MA2, Bussoli TJ2, Kelly A2, Steel KP1 1 Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 2 MRC Institute of Hearing Research, Nottingham, United Kingdom |
|
| 1.41pm –1.53pm |
P31 - The Search for Huntington's Disease
Modifiers in the Mouse
Acevedo A1 , Chrobot N1, Rubinsztein DC2, Brown SD1 1 MRC Mammalian Genetics Unit, Harwell, United Kingdom, 2 Cambridge Institute for Medical Research, Cambridge, United Kingdom |
|
| 1.53pm –2.05pm |
P34 - Coordination of Growth and Metabolism
by the Imprinted Grb10 Gene
Smith FM1 , Charalambous M2, Koumanov F1, Garfield A1, Ward A1 1 Centre for Regenerative Medicine, University of Bath, Bath, United Kingdom, 2 Centre for Diabetes and Endocrinology, Division of Medicine, London, United Kingdom |
|
| 2.05pm –2.17pm |
P37 - Suppressors and Enhancers of Testicular
Cancer Susceptibility in Double-Mutant Mice
Lam MYJ, Youngren KK, Nadeau JH Case Western Reserve University, Cleveland, United States |
|
| 2.17pm – 2.29pm | P46 - Analysis of the Candidate
Region and Candidate Genes Responsible for the Ddk Syndrome
of Embryonic Lethality
de la Casa-Esperon E1 , Gimelbrant A3, Adey B1, Briscoe T1, Hao L1, Wu G1, Chess A3, Pardo-Manuel de Villena F2, Sapienza C 1 1 Fels Institute, Temple University School of Medicine, Philadelphia , PA, United States, 2 Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, United States, 3 Whitehead Institute for Biomedical Research, MIT, Cambridge, MA, United States |
|
| 2.29pm – 2.41pm | P70 - Identification and
Localisation of Mutations in the Del(13)Svea36h
Deletion
McKeone R, Rowe C, Polley S, Wells S, Arkell R, Davies J, Bogani D, Dear N, Denny P MRC Harwell, Didcot, United Kingdom |
|
| 2.41pm – 2.53pm | P11 - Sequence and Haplotype
Analysis of H-Ras and Distal Chromosome 7 in 12
Mouse Inbred Strains Reveals a Strong Ancestral Bias
Drew JC, Kastenmeier AS, Drinkwater NR McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, United States |
|
| 2.53pm – 3.05pm | P6 - Experimental
Confirmation of Enhancer Activity at Lvis1, A
Conserved Gene-Distant Ancient Regulatory Site
Weiser K, Justice MJ Baylor College of Medicine, Houston, United States |
|
| 3.05pm – 3.17pm | P10 - Bioinformatics and
Expression Analysis of Mouse Chromosome 5 (0-75mb
Region)
Shao H1 , Gan T 2, Valladares O1, Manduchi E2, Pinney D2, Stoeckert C2, Bucan M1 1 Department of Genetics, University of Pennsylvania, Philadelphia, United States, 2 Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, United States |
|
| 3.20pm – 3.45pm | Coffee and Tea | |
| 3.45pm – 5.57pm | Student Scholar Symposium II – Modeling Human Disease | |
| 3.45pm – 3.57pm | P61 - ENU Mutagenesis Identifies a
Recessive Mutation in a DNAJ Protein That Results in
Retarded Growth and Polydactyly
Webb T1 , McKie L1, West K1, Peters J2, Cross S1, Jackson I1 1 MRC Human Genetics Unit, Edinburgh, United Kingdom, 2 MRC Mammalian Genetics Unit, Harwell, United Kingdom |
|
| 3.57pm – 4.09pm | P133 - Cross-Species Study of the
Odz Gene Family
Zheng L, Nakamura H, Lossie A, Jafar-Nejad H, Schulze K, Bellen H, Justice MJ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States |
|
| 4.09pm – 4.21pm | P124 - Dynamic Insertional
Mutagenesis Project for the Mouse
Poirier C, Overbeek PA, Adams CP, Harrison WR, Xiao N, Castile CA, Bishop CE Baylor College of Medicine, Houston, United States |
|
| 4.21pm – 4.33pm | P47 - Genome-Wide Association
Analysis Identifies Novel Modifier Loci of Hirschsprung
Disease in Sox10dom Mice
Owens SE1 , Broman KW2, Smith JR1, Southard-Smith EM1 1 Vanderbilt University, Nashville, United States, 2 Johns Hopkins University, Baltimore, United States |
|
| 4.33pm – 4.45pm | P63 - Mutations in theMouse
Axonemal Dynein Heavy Chain, Dnahc2, Result in Male
Infertility
Meehan TP, Justice MJ Baylor College of Medicine, Houston, United States |
|
| 4.45pm – 4.57pm | P151 - A Role for Sonic Hedgehog
in the Cerebellar Deficits of the Ts65dn Mouse Model of
Down Syndrome
Saran NG, Klinedinst DK, Roper RJ, Baxter LL, Beachy PA, Reeves RH Johns Hopkins University School of Medicine, Baltimore, United States |
|
| 4.57pm – 5.09pm | P118 - Apoe Genotype and
Amyloid-Beta Metabolism in a Mouse Model of Alzheimer's
Disease
Mann KM, Lamb BT Department of Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, United States |
|
| 5.09pm – 5.21pm | P53 - Identification of the
Molecular Mechanisms Involved in the Development of
Hairless Phenotype in Near Naked Hairless
(Hrn) Mice
Liu YT1 , Das S2, Olszewski RE2, Lu XC3, Voy BH2 1 University of Tennessee, Knoxville, United States, 2 Oak Ridge National Lab, Oak Ridge, United States, 3 Lawrence Livermore National Laboratory, Livermore, United States |
|
| 5.21pm – 5.33pm | P164 - Correction of Pathological
Aggression in the ‘Fierce’ Mouse by Human
Nuclear Receptor 2e1
Abrahams BS, Kwok MCH, Trinh E, Budaghzadeh S, Hossain SM, Simpson EM University of British Columbia, Vancouver, Canada |
|
| 5.33pm – 5.45pm | P27 - Genetic Variability in
Paraoxonase (Pon1): Relevance for Acute Pesticide Exposure
During Development
Walter BJ1 , Cole TB1, Pettan-Brewer C1, Fisher JC2, Shih DM2, Tward A, Lusis AJ1, Costa LG1, Furlong CE1 1 University of Washington, Seattle, United States, 2 University of Washington, Seattle, United States |
|
| 5.45pm – 5.57pm | P26 - Characterisation of
Shorty, an ENU Derived Mutant Mouse with Defects in
Rib Formation
Harboe TL1 , Herron B2, Beier DR1 1 Genetics Division, Harvard Medical School, Brigham & Women’s Hospital, Boston, United States, 2 Wadsworth Center NYS Department of Health, Albany, United States |
|
| 6.00pm | Dinner | |
| 7.30pm –8.30pm | Interactive Networking
Session - How to Publish in Nature:
Tips for Success in a Changing Scientific World
Chris Gunter Senior Editor, Nature |
|
Monday October 18, 2004
| 9.00am - 6.00pm | Registration Open | |
| 9.00am | Exhibition Set up | |
| 2.00pm-2.15pm | Official Opening of the 18th
International Mouse Genome Conference
Christine Disteche, University of Washington David Adler, ZymoGenetics and University of Washington |
|
| 2.15pm – 3.45pm | Session 1 – Genome Analysis
and Systems Biology
Chair: Yoshihide Hayashizaki |
|
| 2.15pm – 2.45pm | Contemporary Approaches to the
Extract Function from the Mouse Genome
Allan Bradley Director, Wellcome Trust Sanger Institute, Cambridge, United Kingdom |
|
| 2.45pm –3.45pm | Genome Analysis and Systems Biology Papers | |
| 2.45pm – 3.00pm | The Functional Implications of
Linkage Disequilibrium Blocks on Mouse Chromosomes
Paigen K, Petkov PM, Graber JH, Churchill G The Jackson Laboratory, Bar Harbor, ME, United States |
|
| 3.00pm – 3.15pm | Coupled Computational and
Experimental Approaches to Discovery of Coding and
Non-coding Genes in the Mouse Genome
Hughes TR , Morris Q, Zhang W, Babak T, Mohammad N, Shai O, Fehlings M, Aubin J, Van der Kooy D, Rossant J, Bruneau B, Blencowe B, Frey B University of Toronto, Toronto, Canada |
|
| 3.15pm – 3.30pm | Identification of Co-expressed
Gene Clusters in a Comparative Analysis of Transcriptome
and Proteome in Mouse Tissues
Mijalski T 1, Harder A 2, Halder T 2, Kersten M 2, Horsch M 1, Drobyshev A 1, Lottspeich F 3, Hrabe de Angelis M 1, Beckers J 1 1 Institute of Experimental Genetics, GSF – National Research Centre for Environment and Health, Neuherberg, Germany, 2 TopLab GmbH, Proteomics-Division, Martinsried, Germany, 3 Max-Planck-Institute for Biochemistry, Martinsried, Germany |
|
| 3.30pm – 3.45pm | In-Silico Mapping - Use of
Inferred Haplotypes to Define QTLs
Pletcher MT 1, McClurg P 1, Batalov S 1, Su A 1, Bogue M 3, Mural R 2, Paigen B 3, Wiltshire T 1 1 GNF, San Diego, United States, 2 Celera Genomics, Rockville, United States, 3 The Jackson Laboratory, Bar Harbor, ME, United States |
|
| 3.45pm –4.15pm | Tea/Coffee | |
| 4.15pm – 5.45pm | Session 2 –
Manipulation of Genome I
Chair: Martin Hrabe de Angelis |
|
| 4.15pm – 4.45pm | RNAi Directed Therapies for Human
Viral Hepatitis Infection
Dirk Grimm (Mark Kay) Department of Pediatrics and Genetics, Stanford University, United States |
|
| 4.45pm –5.45pm | Manipulation of Genome Papers | |
| 4.45pm – 5.00pm | Region-Specific Saturated
Mutagenesis Using the Sleeping Beauty Transposon
System
Takeda J 1, Keng VW 1, Yae K 1, Hayakawa T 1, Mizuno S 1, Uno Y 2, Kokubu C 1, Horie K 1 1 Dept. of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2 The Institute of Experimental Animal Science, Osaka University, Osaka, Japan |
|
| 5.00pm – 5.15pm | INGENOtyping – An Highly
Efficient Approach to Generate Gene Targeted Mouse and Rat
Models
Laufs J , Sedlmeier R, Peters T, Huffstadt U, Wattler S, Nehls M Ingenium Pharmaceuticals, Martinsried, Germany |
|
| 5.15pm – 5.30pm | Mutations that Cause Heterozygous
Eye Defects are Lethal when Homozygous and Model Human
Disease
Cross SH 1, Hart AW 1, Morgan JE 1, McKie L 1, West K 1, Schneider JE 2, Bhattacharya S 2, Jackson IJ 1 1 MRC Human Genetics Unit, Edinburgh, United Kingdom, 2 Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom |
|
| 5.30pm – 5.45pm | Haplotype Analysis in Multiple
Crosses to Identify a QTL Gene
Wang X , Korstanje R, Higgins D, Paigen B The Jackson Laboratory, Bar Harbor, ME, United States |
|
| 5.45pm –7.15pm | Drinks Reception & Dinner – Sheraton Seattle | |
| 7.30pm –8.30pm | Verne Chapman Memorial
Lecture
25 Years of Transgenic Mice: The Metallothionein Perspective Richard Palmiter Investigator, Howard Hughes Medical Institute And Professor of Biochemistry, University of Washington, Seattle, United States |
|
Tuesday October 19,
2004
Sponsored by Tepnel Life Sciences Plc
Wednesday October 20,
2004
Thursday October 21,
2004
Friday October 22,
2004
8.00am
Registration Open
8.30am –10.15am
Session 3 – Manipulation of
Genome II
Chair: David Threadgill
8.30am – 9.00am
Recombineering: A Powerful New
Tool for Mouse Functional Genomics
Neal Copeland
Director, Mouse Cancer Genetics Program, National Cancer
Institute, Frederick, United States
9.00am –10.15am
Manipulation of Genome II
Papers
9.00am – 9.15am
Somatic Sleeping Beauty
Transposition Provides a Potentially Potent Cancer Gene
Discovery Tool
Jenkins NA , Dupuy AJ, Copeland NG
National Cancer Institute, Frederick, United States
9.15am – 9.30am
Genomic Characterization of
Neuronal Synapse
Yang S 2, Murphy
TK 2, Hadley D 4, Farias
M 2, Kapfhamer D 2, Ungar
L 1, Kim J 3, Bucan
M 1
1 Penn Center for Bioinformatics, University of
Pennsylvania, Philadelphia, United States, 2
Department of Genetics/SOM, University of Pennsylvania,
Philadelphia, United States, 3 Department of
Computer and Information Sciences/SEAS, University of
Pennsylvania, Philadelphia, United States, 4
Department of Biology/SAS, University of Pennsylvania,
Philadelphia, United States
9.30am – 9.45am
Identification of
Region-specific Transcription Factor Genes in the Adult
Mouse Brain by Medium-scale Real-time RT-PCR
Suzuki H , Okunishi R, Hashizume W, Katayama S,
Ninomiya N, Osato N, Sato K, Nakamura M, Iida J,
Kanamori M, Hayashizaki Y
RIKEN GSC, Yokohama, Japan
9.45 – 10.00am
Significance of Genetic Variability
in the Human PON1 Gene Explored in a Mouse Model
Furlong CE 1 , Cole
TB 1 , Richter RJ 1 , Li
WF 1 , Carlson C 1 ,
Nickerson D 1 , Jarvik GP 1
, Lusis AJ 2 , Tward A 2, Shih
D 2 , Costa LG 1
1 University of Washington, Seattle, United
States, 2UCLA, Los Angeles, United States
10.00am – 10.15am
Identification of the IL-17
Receptor-Related Molecule, IL-17RC as a Receptor for IL-17A
and IL-17F
Levin SD, Kuestner R, Brandt C, Gao Z, Ostrander C,
Bort S, Taft D, Bilsborough J, Lewis K, Jaspers S,
Dillon S, Lewis P, Topouzis S, Rixon M, Chan C, Moore M,
Reardon B, Bukowski T, Moore B, West J, Parrish-Novak
J
ZymoGenetics, Inc., Seattle, United States
10.15am – 10.30am
Selected Student Presentation
10.30am –12.30pm
Tea/Coffee and Poster Session I
12.30pm –2.00pm
Lunch
(Nomenclature Committee Meeting)
12.45pm –1.45pm
Lunchtime Session
1.15pm –1.45pm
DNA Extraction from Mouse
Tissue
2.00pm – 3.30pm
Session 4 - Comparative Genome
Analysis
Chair: Ian Jackson
2.00pm – 2.30pm
Sequence of the Mouse Y
Chromosome
Jessica Alfoldi (David Page)
Graduate Student, MIT Whitehead Institute,
Cambridge, United States
2.30pm – 3.30pm
Comparative Genome Analysis
Papers
2.30pm – 2.45pm
Establishing the Functional
Potential of Conserved Non-coding Sequences
Grice EA 1, Emison
E 1, Portnoy ME 2, Rochelle
E 1, NISC Comparative Sequencing
Program 2, Green ED 2,
Chakravarti A 1, McCallion
AS 1
1 McKusick-Nathans Institute of Genetics
Medicine, Johns Hopkins University, Baltimore, United
States, 2 National Human Genome Research
Institute, National Institutes of Health, Bethesda, United
States
2.45pm – 3.00pm
ExactPlus : A Program
for Detecting Small Conserved Genomic Regions by
Multi-Species Sequence Comparisons
Antonellis A 1, Prasad
AB 1, Wolfsberg TG 1, NCS
Program 2, Green ED 1,
Pavan WJ 3
1 Genome Technology Branch, NHGRI, NIH,
Bethesda, United States, 2 NIH Intramural
Sequencing Center, NHGRI, NIH, Gaithersburg, United States,
3 Genetic Disease Research Branch, NHGRI, NIH,
Bethesda, United States
3.00pm – 3.15pm
Polymorphisms Predating the
Divergence of the Mus musculus Subspecies are Very Common
in Inbred Strains
Pardo-Manuel de Villena F 1,
Ideraabdullah FY 1, Doherty
HE 1, Bell TA 1, De la
Casa-Esperon E 2, Detwiler
DA 1, Sapienza C 2
1 Department of Genetics, UNC-Chapel Hill,
Chapel Hill, United States, 2 Fels Institute fro
Cancer Research, temple University School of Medicine,
Philadelphia, United States
3.15pm – 3.30pm
Regulatory and Coding Sequences of
the Pituitary-Specific Transcription Factor, PROP1 are
Evolutionarily and Functionally Conserved
Camper SA 1, Ward
RD 1, Cho M-C 1, Raetzman
LT 1, Esposito C 1, Rubin
EM 2, Smith TPL 3, Rhodes
SJ 4, Lyons RH 1
1 University of Michigan Medical School, Ann
Arbor, MI, United States, 2 DOE Joint Genome
Institute, Walnut Creek, California, United States,
3 USDA/ARS, Meat Animal Research Center, Clay
Center, NE, United States, 4 Indiana
University-Purdue University Indianapolis, United States
3.30pm – 4.00pm
Tea/Coffee
4.00pm – 5.30pm
Session 5 –
Functional Genome Analysis
Chair: Monica Justice
4.00pm – 4.30pm
Functional Genome
Analysis
Tim O’Brien
Staff Scientist, The Jackson Laboratory, Bar Harbor, ME,
United States
4.30pm –5.30pm
Functional Genome Analysis
Papers
4.30pm – 4.45pm
Inflammatory Disease and Abortive
Platelet Shedding Caused by a Mutation in a Pivotal
Modulator of Actin Dynamics in the Redears Mouse
Kile BT 2, Woodward
LS 1, Justice MJ 1
1 Baylor College of Medicine, Houston, United
States, 2 The Walter and Eliza Hall Institute of
Medical Research, Parkville, Australia
4.45pm – 5.00pm
New Insights into Mouse Haplotype
Structure and SNP Haplotype Mapping
Wade CM 1, Frazer
KA 3, Kulbokas EJ 2, Cox
DR 3, Linblad-Toh K 2, Daly
MJ 1
1 Whitehead Institute, Cambridge, MA, United
States, 2 Broad Institute of MIT and Harvard,
Cambridge, MA, United States, 3 Perlegen
Sciences, Mountain View, CA, United States
5.00pm – 5.15pm
Sequence and Phenotype Annotation
of the Tyrp1 Deletion Complex on Chromosome 4
Smyth IM 1, Taylor M 1,
Wilming L 2, Du X 3,
Gautier P 1, Edgar R 1,
White S 1, Cross SH 1,
Botcherby M 4, Rogers J 2,
Campbell RD 4, Brown SDM 5,
Beutler B 3, Justice MJ 6,
Jackson IJ 1
1 MRC Human Genetics Unit, Edinburgh, United
Kingdom, 2 Wellcome Trust Sanger Institute,
Hinxton, United Kingdom, 3 Scripps Research
Institute, La Jolla, United States, 4 MRC
Rosalind Franklin Centre for Genomics Research, Hinxton,
United Kingdom, 5 MRC Mouse Genome Centre,
Harwell, United Kingdom, 6 Baylor College of
Medicine, Houston, United States
5.15pm – 5.30pm
A Mouse Insertional Mutation on
Chromosome 9 Causes Juvenile Hydrocephalus
Schmidt JV , Kalinina EA, Steshina E
University of Illinois at Chicago, Chicago, IL, United
States
5.30pm – 5.45pm
Selected Student Presentation
5.45pm – 6.15pm
Identifying Components of Growth
Factor Signalling Pathways through Gene Trap
Mutagenesis
Philippe Soriano
Fred Hutchison
Cancer Research Center, Seattle, United
States
Free Evening
8.00am
Registration Open
8.30am – 10.15am
Session 6 – Epigenetics and
Modifiers
Chair: Jiri Forejt
8.30am – 9.00am
A Sensitized Screen for Modifiers
of Epigenetic Phenomena
Emma Whitelaw
Associate Professor, University of Sydney, School of
Molecular and Microbiology Biosciences, Sydney, Australia
9.00am –10.15am
Epigenetics and Modifiers
Papers
9.00am – 9.15am
Using ENU Mutagenesis to Identify
New Genes Involved in Epigenetic Gene Regulation
Lossie AC , Justice MJ
Baylor College of Medicine, Houston, United States
9.15am – 9.30am
Genetic Studies of Candidate
Metastasis Modifier Genes on Mouse Chromosome 19
Hunter KW, Park Y-G, Clifford R, Buetow KH
National Cancer Institute, Bethesda, United States
9.30am – 9.45am
Polygeny, Imprinting, and Maternal
Effect Modify Sex Determination in Odd Sex (Ods) Mice
Poirier C 1, Qin
Y 1, Adams CP 1, Anaya
Y 1, Moran JL 2, Beier
DR 2, Nadeau JH 3, Bishop
CE 1
1 Baylor College of Medicine, Houston, United
States, 2 Harvard Medical School, Boston, United
States, 3 Case Western Reserve University,
Cleveland, United States
9.45am – 10.00am
Epigenetic Antagonism at the
H19/Igf2 Imprinting Control Region
Engel NI 1, Bartolomei
MS 2
1University of Pennsylvania, Philadelphia,
United States, 2 Howard Hughes Medical
Institute, Philadelphia, United States
10.00am - 10.15am
Characterization of the
Mom2 Locus: A Spontaneous Mutation Resulting in
Suppression of Intestinal Polyp Formation in
ApcMin Mice
Buchberg AM, Silverman K, Koatkar R, Zeskand J,
McEntee B, Baran A, Grant S, Siracusa LD
Kimmel Cancer Center, Thomas Jefferson University,
Philadelphia, PA 19107, United States
10.15am –10.45am
Tea/Coffee
10.45am – 12.15pm
Session 7 – Development
and Stem Cells
Chair: Karen Artzt
10.45am – 11.15am
Non-coding RNAs Play Multiple
Roles in Inactivation Initiation
Philip Avner
Professor Institut Pasteur, Institut Pasteur, Paris, France
11.15am –12.15pm
Development and Stem Cells
Papers
11.15am – 11.30am
Requirement of Delta1 During
Early Neurogenesis in Mice
Przemeck G 1, Wünsch
K 1, Gossler A 2,
Hrabé de Angelis M 1
1 GSF- National Research Center, Institute of
Experimental Genetics, Neuherberg/Munich, Germany,
2 Institute of Molecular Biology OE5250,
Medizinische Hochschule Hannover, Hannover, Germany
11.30am – 11.45am
The Adrenocortical Dysplasia
(acd) Mouse: Mutation in a Novel Gene Causes a Pleiotropic
Phenotype of Urogenital Defects and Caudal Dysgenesis
Hutz JE 1, Keegan
CE 1, Else T 1, Adamska
M 1, Shah SP 1, Kent
AE 1, Looyenga BD 1,
Howes JM 1, Beamer WG 2,
Hammer GD 1
1 University of Michigan, Ann Arbor, MI, United
States, 2 The Jackson Laboratory, Bar Harbor,
ME, United States
11.45am – 12.00pm
A Global Profile of Gene
Expression in Mouse Primordial Germ Cells
Abe K 1, Sugimoto
M 1, Kobayakawa S 1, Noce
T 2, Qian Y 3, Sharov
A 3, Ko M 3, Mise
N 1
1 RIKEN BRC, Tsukuba, Japan, 2
Mitsubishi Inst Life Sci, Tokyo, Japan, 3
National Inst on Aging, Baltimore, United States
12.00pm – 12.15pm
A Sensitized Mouse Mutagenesis
Screen for Novel Genes Regulating Neural Crest Cell
Development
Watkins-ChowDE , Silver DL, Matera I, Baxter LL,
Elliott G, Rivas C, Incao A, Pavan WJ
National Human Genome Institute, NIH, Bethesda, MD, United
States
12.15pm –1.30pm
Lunch (Mammalian Genome Editorial
Board Meeting)
1.30pm –2.30pm
IMGC Business Meeting
1.30pm –4.00pm
Poster Session II, Tea and
Coffee will be served at 3.30pm
4.00pm –6.00pm
Afternoon Break for Discussion or go
to Pike Street Market
6.00pm –7.30pm
Drinks Reception and Dinner –
Sheraton Hotel
7.30pm – 9.00pm
Session 8 – Genome
Instability and Aging –
Sponsored by the Ellison Foundation
Chair: John Schimenti
7.30pm – 8.00pm
Genome Instability and Aging
George Martin
Professor of Pathology Emeritus, University of Washington,
Seattle, United States
8.00pm –9.00pm
Genome Instability and Aging
Papers
8.00pm – 8.15pm
Chromosomal Instability Leads to
Birth Defects and Cancer Predisposition in
Recql4-Deficient Mice: A Model of Rothmund-Thomson
Syndrome
MannMB , Luo G
Department of Genetics, Case Western Reserve University and
Ireland Cancer Center, University Hospitals of Cleveland,
Cleveland, United States
8.15pm – 8.30pm
Pinkie, the First Viable
Germline Hypomorph Allele of Retinoid X Receptor Alpha,
Reveals an Important Role for
RXRa in Th2
Development
Du X 1, Bigby T 2,
Tabeta K 1, Janssen E 3,
Crozat K 1, Mann N 1,
Beutler B 1
1 The Scripps Research Institute, La Jolla,
United States, 2 VA San Diego Healthcare System
and the University of California, San Diego, United States,
3 La Jolla Institute for Allergy and Immunology,
La Jolla, United States
8.30pm – 8.45pm
Maintaining Telomere and
Chromosome Stability Require the Rad51d Homologous
Recombination Gene
Smiraldo PG 1, Tarsounas
M 3, Gruver AM 1, Osborn
JC 1, Munoz P 2, Class
A 3, Blasco MA 2,
West SC 3, Pittman
DL 1
1 Medical College of Ohio, Toledo, United
States, 2 Spanish National Cancer Center,
Madrid, Spain, 3 Cancer Research UK, London
Research Institute, Hertfordshire, United Kingdom
8.45pm –9.00pm
Studying the Role of the
Kinesin-Like Motor Protein, Eg5, in Tumorigenesis, Genome
Instability, and Aging
Castillo A , Justice MJ
Baylor College of Medicine, Houston, United States
8.00am
Registration Open
8.30am – 10.00am
Session 9 – Genetics of
Infectious Diseases
Chair: Rudi Balling
8.30am – 9.00am
Genetics of Host Susceptibility to
Cytomegalovirus Infection: Role of H2 and NK Receptors
Silvia Vidal,
Associate Professor, McGill
University, Montreal, Canada
9.00am –10.00am
Genetics of Infectious Diseases
Papers
9.00am – 9.15am
A TLR2-responsive Lipid Effector
Pathway Protects Mammals Against Gram-positive Bacterial
Skin Infections
Georgel P , Crozat K, Lauth X, Sovath S, Hoebe K, Du
X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Beutler B
1 TSRI, La Jolla, United States, 2
UCSD, San Diego, United States
9.15am – 9.30am
Sex Dependent Susceptibility
Pattern to Listeria Monocytogenes Infection is
Mediated by Differential IL-10 Production
Kalaydjiev S 1, Pasche B 2,
Franz TJ 1, Kremmer E 3,
Gailus-Durner V 4, Fuchs
H 4, Hrabe de Angelis
M 1, Busch DH 1,
Lengeling A 2
1 Institute for Medical Microbiology,
Immunology, and HygieneTechnical University Munich, Munich,
Germany, 2 Junior Research Group Infection
Genetics, German Research Centre for Biotechnology (GBF),
Braunschweig, Germany, 3 Institute of Molecular
Immunology, GSF - National Research Center for Environment
and Health, Munich, Germany, 4 German Mouse
Clinic, Institute of Experimental Genetics, GSF - National
Research Center for Environment and Health, Neuherberg,
Germany
9.30am – 9.45am
Mechanism of Resistance to
Plasmodium Chabaudi in Mice is Mediated through the Red
Cell and a Totally Synergistic Non-Erythrocytic Pathway
Lin E, Marshall V, Burt RA, Foote SJ
The Walter & Eliza Hall Institute, Parkville, Australia
9.45am – 10.00am
Risk Assessment of Mouse
Hepatitis Infection (MHV) Via In vitro Fertilization
And Embryo Transfer with Intact and Laser Microdissected
Oocytes
Peters D 1, Marschall
S 1, Mahabir E 2, Schmidt
J 2, Hrabé de Angelis
M 1
1 Institute of Experimental Genetics,
GSF-National Research Center for Environmental and Health,
Neuherberg, Germany, 2 Department of Comparative
Medicine, GSF-National Research Center for Environmental
and Health, Neuherberg, Germany
10.00am –10.15am
Selected Student Presentation
10.15am –12.30pm
Tea/Coffee and Poster Session III
12.30pm –1.30pm
Lunch
1.30pm – 3.15pm
Session 10 – Models of Human
Diseases
Chair: Maja Bucan
1.30pm – 2.00pm
Genetics of Atherosclerosis:
Integrating Genetic and Gene Expression Data
Aldons Lusis
Professor, University of California, Los Angeles, United
States
2.00pm –3.00pm
Models of Human Diseases
Papers
2.00pm – 2.15pm
Jenna : A novel ENU
Hyperactive Mouse Mutant with an Enhanced Acoustic Startle
Response
Keays DA 1 , Nolan
P 2 , Oliver P 3 , Tian
G 4, Fullerton J 1 , Rees
M 5 , Harvey RJ 6 , Cowan
NJ 4 , Davies KE 3 , Flint
J 1
1 Wellcome Trust Centre for Human Genetics,
Oxford University, Oxford, United Kingdom,
2 MRC Mammalian Genetics Unit, Harwell, Didcot,
United Kingdom, 3 Department of Human Anatomy
and Genetics, Oxford University, Oxford, United Kingdom,
4 Department of Biochemistry, New York
University Medical Center, New York, United States,
5 Swansea Clinical School , University of Wales
Swansea, Singleton Park, Swansea, United Kingdom,
6 Department of Pharmacology, The School of
Pharmacy, London, United Kingdom
2.15pm – 2.30pm
Estimating the Contribution of
Genetic, Diet and Gender Effects to the Phenotypic
Variation Observed in Metabolic Syndrome-Related Traits
between A/J and C57BL/6J Mice
Sinasac DS , Nadeau JH
Case Western Reserve University, Cleveland, United States
2.30pm-2.45pm
Mutant Analysis Reveals Whirlin as a Dynamic
Organiser in the Growing Hair Cell Stereocilium
Kikkawa Y 1, Mburu P 1,
Morse S 1, Kominami R 2,
Townsend S 1, Brown
S 1
1 MRC, Harwell, United Kingdom, 2
Tokyo Metropolitan Institute of Medical Science
(Rinshoken), Tokyo, Japan
2.45pm – 3.00pm
Discovery of a Gene Causing Human
Congenital Diaphragmatic Defect and Pulmonary Hypoplasia by
Characterization of an ENU-Induced Mouse Model
Ackerman KG 1, Vargas SO 2,
Beier DR 1
1 Brigham and Women's Hospital/Harvard Med Sch,
Boston, United States, 2 Children's
Hospital/Harvard Med Sch, Boston, United States
3.00pm – 3.15pm
ENU-induced Mouse Enamelin
(Enam) Mutants as Models for Different Clinical
Subtypes of Human Amelogenesis Imperfecta (AI)
Masuya H 1, Shimizu
K 2, Sezutsu H 1, Sakuraba
Y 1, Nagano J 1, Shimizu
A 1, Fijimoto N 1, Ishijima
J 1, Kaneda H 1, Kobayashi
K 1, Maeda T 2, Gondo
Y 1, Noda T 1, Wakana
S 1, Shiroishi T 1
1 RIKEN GSC, Tsukuba, Japan, 2 Nihon
University, Matsudo, Japan
3.15pm –3.30pm
Closing remarks
4.30pm
Coaches Depart for waterfront to board boat
5.00pm-10.00pm
Cruise to music followed by a banquet dinner
at Kiana Lodge
7.30am – 9.00am
Breakfast and depart