18th International Mouse Genome Conference
17-22 October 2004, Seattle, USA
Plenary Presentations * Oral
Presentations * Poster
Abstracts * Photos
Verne Chapman Memorial Lecture * Table
of Contents * Attendees * Awards
Functional Genome Analysis
POSTERS 53 - 85
53. IDENTIFICATION OF
THE MOLECULAR MECHANISMS INVOLVED IN THE DEVELOPMENT OF HAIRLESS PHENOTYPE IN
NEAR NAKED HAIRLESS (HRN) MICE
Liu YT 1, Das
S 2, Olszewski RE 2, Lu
XC 3, Voy BH 2
1 University of Tennessee, Knoxville, United
States, 2 Oak Ridge National Lab, Oak Ridge,
United States, 3 Lawrence Livermore National
Laboratory, Livermore, United States
54. IDENTIFICATION OF
MULTIPLE GENETIC LOCI LINKED TO LUNG FUNCTION IN MICE
Reinhard C 1, Meyer
B 3, Fuchs H 2, Stöger
T 1, Eder G 1,
Rüschendorf F 3, Heyder
J 1, Nürnberg P 3,
Hrabé de Angelis M 2, Schulz
H 1
1 Institute for Inhalation Biology, GSF-Research
Center for Environment and Health, Neuherberg/Munich,
Germany, 2 Institute of Experimental Genetics,
GSF-Research Center for Environment and Health,
Neuherberg/Munich, Germany, 3 Gene Mapping Center,
Max-Delbrück-Centrum, Berlin, Germany
55. 'ANONYMUS' - A LABORATORY
INFORMATION MANAGEMENT SYSTEM FOR THE CAPTURE AND DISSEMINATION OF ANIMAL HUSBANDRY
AND EXPERIMENTAL DATA
Jones JD 1, Brundrett
AC 1, Chandrasekar K 2, Jones
PJR 1, Olver GH 2, Oxspring
RJ 1, Seymour M 1, Selley
RL 1, Johnson R 1
1 Mary Lyon Centre, Medical Research Council,
Harwell, United Kingdom, 2 Prion Unit, Medical
Research Council, London, United Kingdom
56. IMPAIRED THALAMIC
SENSORY GATING AND AFFECTIVE DISORDER IN T-TYPE CA2+ CHANNEL MUTANTS
Shin H-S, Choi S, Lee J, Lee S, Kim C, Kim D
Korea Institute of Science & Technology, Seoul, Korea,
South
57. A GENETIC ANALYSIS
OF BEHAVIORAL DIVERSITY BETWEEN WILD-DERIVED MOUSE STRAIN, MSM/MS AND C57BL/6
Nishi A 1, Nishi
A 3, Yonekawa H 2, Shiroishi
T 1, Shiroishi T 4, Koide
T 1, Koide T 3
1 The Graduate University of Advanced Studies,
Hayama, Japan, 2 The Tokyo Metropolitan Institute
of Medical Science, Tokyo, Japan, 3 Mouse Genomics
Resource Laboratory, National Institute of Genetics, Mishima,
Japan, 4 Mammalian Genetics Laboratory, National
Institute of Genetics, Mishima, Japan
58.
DESCRIPTIVE AND TEMPORAL ANALYSIS OF THE OPEN-FIELD BEHAVIOR IN WILD-DERIVED MOUSE
STRAINS
Takahashi A 1, Takahashi
A 4, Yonekawa H 2, Shiroishi
T 1, Shiroishi T 3, Koide
T 1, Koide T 4
1 The Graduate University of Advanced Studies,
Mishima, Japan, 2 The Tokyo Metropolitan Institute
of Medical Science, Tokyo, Japan, 3 Mammalian
Genetics Laboratory, National Institute of Genetics, Mishima,
Japan, 4 Mouse Genomics Resource Laboratory,
National Institute of Genetics, Mishima, Japan
59. GENETIC AND BIOCHEMICAL
CHARACTERIZATION OF AN ALLELIC SERIES OF SMAD4 MUTATIONS IDENTIFIED IN
AN ENU-MUTAGENIZED MOUSE EMBRYONIC STEM CELL LIBRARY
Chen Y, Yee D, Magnuson T
University of North Carolina-Chapel Hill, Chapel Hill, United
States
60. IDENTIFICATION OF
POSITIONAL CANDIDATE GENES FOR GROWTH AND OBESITY
Aksu S, Neuschl C, Renne U, Koczan D, Thiesen HJ,
Brockmann GA
Humboldt-University of Berlin, Berlin, Germany
61. ENU MUTAGENESIS
IDENTIFIES A RECESSIVE MUTATION IN A DNAJ PROTEIN THAT RESULTS IN RETARDED GROWTH
AND POLYDACTYLY
Webb T 1, McKie L 1, West K
1, Peters J 2, Cross SH 1,
Jackson I 1
1 MRC Human Genetics Unit, Edinburgh, United
Kingdom and 2 MRC Mammalian Genetics Unit,
Harwell, United Kingdom
62. THE MOUSE JUVENILE
SPERMATOGONIAL DEPLETION (JSD) PHENOTYPE IS DUE TO A MUTATION IN MUTP14B, A
MEMBER OF THE SNORNP COMPLEX
Rohozinski J 1, Bishop CE
2
1 Baylor College of Medicine, Dept. Obstetrics
& Gynecology, Houston, United States, 2 Baylor
College of Medicine, Dept. Molecular & Human Genetics,
Houston, United States
63. MUTATIONS IN THE
MOUSE AXONEMAL DYNEIN HEAVY CHAIN, DNAHC2, RESULT IN MALE INFERTILITY
Meehan TP, Justice MJ
Baylor College of Medicine, Houston, United States
64. MOUSE DEAFNESS MUTANT
LINES FROM THE RIKEN ENU MUTAGENESIS PROJECT
Minowa O, Inoue M, Sakuraba Y, Motegi H, Toki H,
Tada M, Kaneda H, Ishijima J, Masuya H, Kobayashi K, Suzuki
T, Wakana S, Gondo Y, Shiroishi T, Noda T
RIKEN-GSC, Yokohama, Japan
65. MICROARRAY ANALYSIS
OF GENE EXPRESSION AT THE DEL(13)SVEA36H
REGION OF MOUSE CHROMOSOME 13 DURING POSTIMPLANTATION MOUSE DEVELOPMENT
Willoughby C 1, Davies
J 1, Underhill P 1, Holmes
C 1, Greenfield A 1, Denny
P 1, Ragoussis J 2, Arkell
R 1
1 Mammalian Genetics Unit, MRC Harwell,
Oxfordshire, United Kingdom, 2 Wellcome Trust
Centre for Human Genetics, Oxford, United Kingdom
66. MAPPING AND POSITIONAL
CLONING OF ENU-INDUCED MOUSE DEVELOPMENTAL MUTANTS WITH A WHOLE GENOME SNP PANEL
AND EXON-BASED SEQUENCING
Moran JL 1, Yun
Y 1, Brown A 1, Bjork
BC 1, Tran P 1, Li
C 2, Salinger AP 3, Poirier
C 3, Zhang B 1, Montgomery
K 1, Bishop C 3, Justice
M 3, Wiltshire T 4,
Kwiatkowski DJ 1, Kucherlapati
R 1, Beier DR 1
1 Brigham and Women's Hospital, Harvard Medical
School, Boston, MA, United States, 2 Dana Farber
Cancer Institute, Harvard School of Public Health, Boston,
MA, United States, 3 Baylor College of Medicine,
Houston, TX, United States, 4 Genomics Institute
of the Novartis Research Foundation, San Diego, CA, United
States
67. PHENOTYPE OR GENOTYPE?
THE ORGANISM FROM DIFFERENT BIOLOGICAL PERSPECTIVES
Eppig JT, van den Borre P, Lu I, Anagnostopoulos A,
Burkart DL, Cassell MA, Dene H, Bello SM, Washburn LL, Lutz
CM, Goldsmith CW, Smith CL
The Jackson Laboratory, Bar Harbor, United States
68. SOPDB: A RESOURCE
OF STANDARD OPERATING PROCEDURES FOR MOUSE PHENOTYPING
Green ECJ, Gkoutos GV, Weekes J, Mallon AM, Hancock JM
Mammalian Genetics Unit, Oxfordshire, United Kingdom
69. STUDY OF THE
GENES INVOLVED IN THE HYPERTROPIC LANGERHANS ISLAND OF THE KK-AY
MOUSE AND THEIR HISTOLOGICAL LOCALIZATION
Kusakabe M 1, Matsuba
K 2, Inoue J 2, Aotsuka
S 2, Hokao R 1, Hashimoto
H 3
1 Institute for Animal Reproduction, Ibaraki,
Japan, 2 ANB Tsukuba Institute, Aloka Co., Ltd.,
Ibaraki, Japan, 3 Jikei Univ. Sch of Med., Dept.
Anat., Tokyo, Japan
70. IDENTIFICATION AND
LOCALISATION OF MUTATIONS IN THE DEL(13)SVEA36H DELETION
McKeone R, Rowe C, Polley S, Wells S, Arkell R, Davies
J, Bogani D, Dear N, Denny P
MRC Harwell, Didcot, United Kingdom
71. BEHAVIORAL CHARACTERIZATION
AND LINKAGE ANALYSIS OF AN ENU-INDUCED MOUSE MUTANT LINE THAT SHOWS LEARNING
DEFICIT, REDUCTION OF BODY SIZE, CONVULSIVE SEIZURE, AND TRANSIENT IMMOBILITY
Furuse T, Wada Y, Masuya H, Kaneda H, Kobayashi K,
Kawai A, Kushida T, Nishii R, Gondo Y, Noda T, Wakana S,
Shiroishi T
RIKEN GSC, Tsukuba, Japan
72. THE NOX3
AND NOXO1 GENES, ENCODING PRESUMPTIVE MEMBERS OF AN NADPH OXIDASE COMPLEX,
ARE REQUIRED FOR NORMAL VESTIBULAR FUNCTION AND DEVELOPMENT
Bergstrom DE 1, Bergstrom
RA 1, Munroe RJ 2, Schimenti
JC 2, Gagnon LH 1, Johnson
KR 1, Heinzmann U 3, Stumm
G 4, Paffenholz R 4
1 The Jackson Laboratory, Bar Harbor, United
States, 2 Cornell University, Ithaca, United
States, 3 GSF-National Research Center for
Environmental Health, Neuherberg, Germany, 4
Ingenium Pharmaceuticals, Martinsried, Germany
73. HOLOPROSENCEPHALY
AT DEL(13)SVEA36H
Bogani D 1, Willoughby
C 1, Mirza G 2, Davies
J 1, Ragoussis I 2, Arkell
R 1
1 Mammalian Genetics Unit, Medical Research
Council, Harwell, Didcot, United Kingdom, 2
Wellcome Trust Centre for Human Genetics, Department of
Genomics, Oxford, United States
74. CHARACTERIZATION
OF THE REGULATORY MUTATION MVWF1, A MAJOR CAUSE OF PROLONGED APTTS IN
MICE
Johnsen J 1, Ginsburg
D 2
1 University of Michigan, Ann Arbor, United
States, 2 Howard Hughes Medical Institute, Ann
Arbor, United States
75. GENETICS OF GENE
EXPRESSION OF THE INSULIN SIGNALING PATHWAY IN POLYGENIC OBESITY
Ferrell AD, Allan MF, Pomp D
University of Nebraska, Lincoln, United States
76. TWO NOVEL ENU-INDUCED
CIRCADIAN RHYTHM MUTANTS IN MICE
Siepka SM 1, McGurk
R 1, Chen M 1, Marusawa
A 1, Olson D 1, Walkowiak
J 1, Pinto L 1, Takahashi
JS 2
1 Center for Functional Genomics, Northwestern
University, Evanston, United States, 2 Howard
Hughes Medical Institute, Evanston, United States
77. AN INSERTION OF
A RETROTRANSPOSON IN THE EDNRB GENE CAUSES PIEBALD COAT COLOR OF THE
S/S MOUSE
Ohtani S 1, Yamada
T 2, Sakurai T 2, Tsuji
T 1, Yanagisawa M 2, Kunieda
T 1
1 Graduate School of Natural Science and
Technology, Okayama University, Okayama, Japan, 2
Howard Hughes Medical Institute, Department of Molecular
Genetics University of Texas Southwestern Medical Center,
Dallas, United States
78. DOSAGE COMPENSATION
BY UP-REGULATION OF X-LINKED GENES: MICROARRAY REVEALS TISSUE-SPECIFIC DIFFERENCES
Nguyen DK, Disteche C
University of Washington, Seattle, United States
79. COMPARATIVE ANALYSIS
OF THE NR1I3 LOCUS BETWEEN THE APN STRAIN AND A CHROMOSOME 1 APN.C3H/HEJ CONGENIC
STRAIN WITH AN ALTERED DRUG METABOLISM PHENOTYPE
Casley WL, Le Blanc CA, Lavigne L, Nowakowska M
Health Canada, Ottawa, Canada
80. IMPROVING EFFICIENCY
OF TRANSGENIC RAT PRODUCTION
Filipiak WE, Saunders TL
University of Michigan Transgenic Core Facility, Ann Arbor,
United States
81. RECIPROCATING WNT-
AND BMP-DEPENDENT PATHWAYS DRIVE CARDIOGENESIS IN P19CL6 CELLS
Chen M 2, Asakura
M 1, Nakamura T 1, Inoue
H 1, Schneider M 1
1 Baylor College of Medicine, Houston, United
States, 2 Agilent Technologies, Palo Alto, United
States
82. EPIGENETIC EVENTS
INFLUENCE THE VARIATION IN INBRED MOUSE STRAIN INNATE IMMUNE RESPONSES
Wells CA 1, Aung
H 1, Himes R 1, Forrest
A 1, Ravasi T 1, Grimmond
S 1, Kasukawa T 2, Carninci
P 2, Hayashizaki Y 3, Hume
D 1
1 IMB, University of QLD, Brisbane, Australia,
2 RIKEN Genome Sciences, Wako, Japan,
3 RIKEN Genome Sciences, Yokohama, Japan
83. DEVELOPMENT OF A
WHOLE MOUSE GENOME MICROARRAY WITH EMPIRICALLY OPTIMIZED 60-MER OLIGONUCLEOTIDE
PROBES USING AGILENT’S SUREPRINT TECHNOLOGY
Collins PJ, Sun H, Gao J, Nguyen K, Lin E, Doan TB,
Giles S, Tang S, Fulmer-Smentek SB, Shannon KW, Webb PG
Agilent Technologies, Inc., Palo Alto, United States
84. THE MOUSE PANCCHIP:
HIGH THROUGHPUT GENE EXPRESSION ANALYSIS OF THE ENDOCRINE PANCREAS
Mazzarelli J 1, White
P 1, Gorski R 1, Brestelli
J 1, Arsenlis A 1, Manduchi
E 1, Katokhin A 2, Belova
O 2, Bogdanova V 2,
Elisafenko E 2, Gubina M 2,
Nizolenko L 2, Perelman P 2,
Puzakov M 2, Shilov A 2,
Trifonoff V 2, Vorobjeva N 2,
Voronin D 2, Zykov I 2,
Kolchanov N 2, Kaestner K 1,
Stoeckert C 1
1 University of Pennsylvania, Philadelphia, United
States, 2 Institute of Cytology and Genetics SB
RAS, Novosibirsk, Russia
85. Functional
Annotation of Human Genes by Gene-Driven ENU Mutagenesis in Mice
Michaud EJ 1,2, Culiat
CT 1,2, Barker G 1, Cain
KT 1, Carpenter DJ 1, Easter
LL 1, Foster CM 1, Gardner
AW 1, Geiger J 3, Guo
ZY 3, Houser KY 1, Hughes
LA 1, Kerley MK 1, Klebig
ML 1,2, Liu Z 3, Olszewski
RE 1, Pinn I 1, Shaw
GD 1, Shinpock SG 1, Wymore
AM 1, Johnson DK 1,2, Rinchik
EM 1,2,4 - 1 Life Sciences Division,
Oak Ridge National Laboratory, Oak Ridge, TN, United States
2The University of Tennessee–Oak Ridge
National Laboratory Graduate School of Genome Science and
Technology, Oak Ridge, TN; United States,
3SpectruMedix, PA, United States
4Department of Biochemistry, Cellular, and
Molecular Biology, The University of Tennessee, Knoxville,
TN, United States